{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_2016_0089396_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"096-677-896-925-767"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11644,"type":"PATENT","title":"The University of New South Wales - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1800,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8310,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:new AND south AND wale
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Add to collection. Total patents: 1108
Search Applicants and Owners separately:new AND south AND wale
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Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 1108
exposing said biofilm to an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent;\n
treating a surface or medium susceptible to biofilm formation with an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent;\n
incorporating an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent in a surface or medium susceptible to biofilm formation; or\n
inducing the accumulation of an effective amount of one or more reactive oxygen or nitrogen species within microorganisms within said biofilm or capable of forming a biofilm."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the at least one nitric oxide generating or releasing agent comprises one or more nitric oxide donors."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2 wherein the at least one nitric oxide donor is sodium nitroprusside, S-nitroso-L-glutathione, S-nitroso-N-acetylpenicillamine or a combination thereof."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the microorganisms present in the biofilm or capable of forming a biofilm are of a single species."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the microorganisms present in the biofilm or capable of forming a biofilm are of multiple species."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the microorganisms within said biofilm or capable of forming a biofilm comprise bacterial or fungal species."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the microorganisms within said biofilm or capable of forming a biofilm comprise one or more species selected from Candida spp., Hormoconis spp., Pseudomonas spp., Pseudoalteromonas spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Mycobacterium spp., Enterococcus spp., Escherichia spp., Salmonella spp., Legionella spp., Haemophilus spp., Bacillus spp., Desulfovibrio spp., Shewanella spp., Geobacter spp., Klebsiella spp., Proteus spp., Aeromonas spp., Arthrobacter spp., Micrococcus spp., Serratia spp., Porphyromonas spp., Fusobacterium spp. and Vibrio spp."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the microorganisms within said biofilm or capable of forming a biofilm comprise one or species selected from P. aeruginosa, Staphylococcus epidermidis, Escherichia coli, Bacillus licheniformis, Serratia marcescens, Fusobacterium nucleatum, Vibrio Cholerae, and Candida albicans. "],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, further comprising treating said surface or medium with, incorporating in said surface or medium, or exposing the microorganisms within said biofilm or capable of forming a biofilm to, at least one antimicrobial agent."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9 wherein the antimicrobial agent is selected from an antibiotic, a surfactant, an oxidative stress-inducing agent, or a combination thereof."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the one or more reactive oxygen or nitrogen species are selected from peroxynitrite, nitric oxide, hydrogen peroxide and superoxide radicals, or a combination thereof."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein said method comprises inducing differentiation events in microorganisms within said biofilm which lead to dispersal or wherein said method comprises preventing induction of differentiation events in microorganisms which lead to biofilm formation."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 which comprises increasing the sensitivity of a microorganism to one or more antimicrobial agents."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the effective amount comprises a concentration of at least one nitric oxide generating or releasing agent of from about 1 nM to about 10 mM."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the effective amount comprises a concentration of at least one nitric oxide generating or releasing agent of from about 10 nM to about 5 μM."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the effective amount comprises a concentration of at least one nitric oxide generating or releasing agent of from about 10 nM to about 1 μM."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 comprising administering to a subject an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent for the treatment or prevention of a biofilm-associated condition in said subject."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17 further comprising administering to said subject at least one antimicrobial agent."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["19.-36. (canceled)"],"number":-1,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}