US 2015/0297618 A1 - Methods Of Treating Acne - The Lens - Free & Open Patent and Scholarly Search

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US 2015/0297618 A1

Abstract

A method of treating acne in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat acne but has substantially no antibiotic activity, without administering a bisphosphonate compound.

Claims

A method for treating acne in a human in need thereof, the method comprising
administering orally to said human doxycycline, or a pharmaceutically acceptable salt thereof,

in an amount that

(i) is effective to treat acne;

(ii) is 10-80% of a 50 mg dose of doxycycline; and

(iii) results in no reduction of skin microflora during a six-month treatment, without administering a bisphosphonate compound.
The method according to claim 1, wherein said doxycycline is doxycycline monohydrate.
The method according to claim 2, wherein said doxycycline monohydrate is administered in an amount of 40 milligrams.
The method according to claim 3, wherein said doxycycline monohydrate is administered by sustained release.
A method according to claim 4, wherein said doxycycline monohydrate is administered once a day.
The method according to claim 2, wherein said doxycycline monohydrate is administered in a dose of 20 mg twice a day.
The method according to claim 1, wherein said doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 μg/ml.
A method for treating acne in a human in need thereof, the method comprising
administering orally to said human doxycycline, or a pharmaceutically acceptable salt thereof,

in an amount that

(i) is effective to treat acne;

(ii) is 40-80% of a 50 mg dose of doxycycline; and

(iii) results in no reduction of skin microflora during a six-month treatment, without administering a bisphosphonate compound.
The method according to claim 8, wherein said doxycycline is doxycycline monohydrate.
The method according to claim 9, wherein said doxycycline monohydrate is administered in an amount of 40 milligrams.
The method according to claim 10, wherein said doxycycline monohydrate is administered by sustained release.
A method according to claim 11, wherein said doxycycline monohydrate is administered once a day.
The method according to claim 9, wherein said doxycycline monohydrate is administered in a dose of 20 mg twice a day.
The method according to claim 8, wherein said doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 μg/ml.
A method for treating acne in a human in need thereof, the method comprising
administering orally to said human doxycycline, or a pharmaceutically acceptable salt thereof, in an amount of 40 mg per day, wherein the amount results in no reduction of skin microflora during a six-month treatment, without administering a bisphosphonate compound.
The method according to claim 15, wherein said doxycycline is doxycycline monohydrate.
The method according to claim 16, wherein said doxycycline monohydrate is administered by sustained release.
A method according to claim 17, wherein said doxycycline monohydrate is administered once a day.
The method according to claim 16, wherein said doxycycline monohydrate is administered in a dose of 20 mg twice a day.
The method according to claim 15, wherein said doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 μg/ml.

Owners (US)

Galderma Labortories Inc (Jul 29 2008)
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Collagenex Pharmaceuticals Inc (Jul 20 2002)
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Applicants

Galderma Lab Inc
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Inventors

Ashley Robert A
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CPC Classifications

A61K31/135
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A61K31/65
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A61K9/0053
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D06M16/00
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IPC Classifications

A61K31/65
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Document History

Publication: Oct 22, 2015
US 2015/0297618 A1
Application: Jun 29, 2015
US 201514753544 A
Priority: Jun 29, 2015
US 201514753544 A
Priority: Dec 9, 2013
US 201314101030 A
Priority: Mar 15, 2013
US 201313838559 A
Priority: Oct 20, 2011
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Priority: Oct 22, 2007
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Priority: Jan 14, 2004
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Priority: Apr 5, 2002
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Priority: Sep 26, 2001
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Priority: Apr 5, 2001
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