{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_2013_0345322_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"184-625-208-307-582","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":6803,"type":"PATENT","title":"CSIRO Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":16949,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8686,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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Search applicants and Owners(US) repectively = ' Commonw* Scie* Indu* Res* Org* ', 'Commonw* Scien* Indus* Res* NEAR Aus*', 'Commonw* Scien* Indus* Res* Orga*', \"Com* Sci* Ind* Res* Org*\", 'Com* Sci* AND Ind* Res* Org*'
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Total patents = 19058
Copied from Raj's patent collection ' CSIRO Patent'.
............ Annie's search:
Search applicants and Owners(US) repectively = ' Commonw* Scie* Indu* Res* Org* ', 'Commonw* Scien* Indus* Res* NEAR Aus*', 'Commonw* Scien* Indus* Res* Orga*', \"Com* Sci* Ind* Res* Org*\", 'Com* Sci* AND Ind* Res* Org*'
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Total patents = 19058
i) determining the presence and/or level of at least two biomarkers selected from the group consisting of IL-8, IGFBP2, MAC2BP, M2PK, IL-13, DKK-3, EpCam, MIP1β, TGFβ1, and TIMP-1 in a sample from the subject,\n
wherein the presence and/or level of the two biomarkers is indicative of colorectal cancer."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the two biomarkers selected from M2PK, EpCam, IL-13, DKK-3, IL-8 and IGFBP2."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises determining the presence and/or level of expression of at least three of the biomarkers."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the three biomarkers are selected from the group consisting of M2PK, EpCam, IL-13, DKK-3, IL-8, IGFBP2, MIP1β, TGFβ1 and MAC2BP."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, wherein the three biomarkers are as follows:\n
i) DKK-3, M2PK, and IGFBP2;\n
ii) M2PK, IGFBP2, and EpCAM;\n
iii) M2PK, MIP1β, and TGFβ1; or\n
iv) IL-8, IL-13, and MAC2BP."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises determining the presence and/or level of expression of at least four of the biomarkers."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein four biomarkers are as follows:\n
i) DKK-3, M2PK, MAC2BP, and IGFBP2;\n
ii) IL-8, IL-13, MAC2BP, and EpCam;\n
iii) DKK3, M2PK, TGFβ1, and TIMP-1;\n
iv) M2PK, MIP1β, IL-13, and TIMP-1; or\n
v) IL-8, MAC2BP, IGFBP2, and EpCam."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises determining the presence and/or level of at least five of the biomarkers."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises determining the presence and/or level of at least six of the biomarkers."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises determining the presence and/or level of at least seven of the biomarkers."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises determining the presence and/or level of at least eight of the biomarkers."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises determining the presence and or level of at least nine of the biomarkers."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises determining the presence and/or level of at least ten of the biomarkers."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises detecting the presence and/or level of least one additional biomarker selected from the group consisting of ICF-I, IGF-II, IGF-BP2, Amphiregulin, VEGFA, VEGFD, MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, TIMP-1, TIMP-2, ENA-78, MCP-1, MIP-1β, IFN-γ, IL-10, IL-13, IL-1β, IL-4, IL-8, IL-6, MAC2BP, Tumor M2 pyruvate kinase, M65, OPN, DKK-3, EpCam, TGFβ-1, and VEGFpan."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method diagnoses or detects colorectal cancer with a sensitivity of at least 50%."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method diagnoses or detects Dukes Stage A colorectal cancer with a sensitivity of at least 50% and a specificity of at least 95%; a sensitivity of at least 60% and a specificity of at least 80%; or a sensitivity of at least 50% and a specificity of at least 90%."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises:\n
i) determining the presence and/or level of the biomarkers in the sample from the subject; and\n
ii) comparing the presence and/or level of the biomarkers relative to a control, wherein a presence and/or level in the sample that is different to the control is indicative of colorectal cancer."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the sample comprises blood, plasma, serum, urine, platelets, magakaryocytes or faeces."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["A method of treatment comprising:\n
(i) diagnosing or detecting colorectal cancer according to the method of claim 1; and\n
(ii) administering a therapeutic suitable for the treatment of colorectal cancer."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["A method for monitoring the efficacy of treatment of colorectal cancer in a subject, the method comprising treating the subject for colorectal cancer and then detecting the presence and/or level of at least two biomarkers selected from IL-8, IGFBP2, MAC2BP, M2PK, IL-13, DKK-3, EpCam, MIP1β, TGFβ1, and TIMP-1 in a sample from the subject, wherein an absence of and/or reduction in the level of expression of the biomarkers after treatment as compared with before treatment is indicative of an effective treatment."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["(canceled)"],"number":31,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}