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Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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administering to the subject a therapeutic antibody that binds Aβ;\n
wherein the subject has an elevated blood level of Aβ40 or Aβ42 as compared to a preselected control value at a time interval after administration of a diagnostic antibody that binds an epitope contained within positions 13-28 of Aβ."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein the time interval is less than 1 week."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein the time interval is less than or equal to 24 hours."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein the time interval is less than or equal to 3 hours."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein the subject is human and the diagnostic antibody is a humanized antibody or an epitope-binding fragment thereof."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the humanized antibody or epitope-binding fragment thereof comprises a light chain of the sequence given by SEQ ID NO:11 and a heavy chain of the sequence given by SEQ ID NO:12."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the humanized antibody or epitope-binding fragment thereof comprises a light chain of the sequence given by SEQ ID NO:11 and a heavy chain of the sequence given by SEQ ID NO:16."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the humanized antibody or epitope-binding fragment thereof comprises a light chain comprising a variable region of the sequence given by SEQ ID NO:7 and a heavy chain comprising a variable region of the sequence given by SEQ ID NO:14."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the humanized antibody or epitope-binding fragment thereof comprises:\n
(a) a light chain comprising three light chain complementarity determining regions (CDRs) having the following amino acid sequences:\n\nlight chain CDR1:(SEQ ID NO: 1)1 5 10 15Arg Ser Ser Gln Ser Leu Ile Tyr Ser Asp Gly Asn Ala Tyr Leu His;or (SEQ ID NO: 17)1 5 10 15Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Ala Tyr Leu His light chain CDR2:(SEQ ID NO: 2)1 5Lys Val Ser Asn Arg Phe Serand light chain CDR3:(SEQ ID NO: 3)1 5Ser Gln Ser Thr His Val Pro Trp Thr \n
and a light chain framework sequence from a humanized immunoglobulin light chain; and\n
(b) a heavy chain comprising three heavy chain CDRs having the following amino acid sequences:\n\nheavy chain CDR1:(SEQ ID NO: 4)1 5Arg Tyr Ser Met Ser heavy chain CDR2:(SEQ ID NO: 5)1 5 10 15Gln Ile Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Thr Val Lys Gly;or (SEQ ID NO: 18)1 5 10 15Gln Ile Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Ser Val Lys Glyand heavy chain CDR3:(SEQ ID NO: 6)1Gly Asp Tyr\n
and a heavy chain framework sequence from a humanized immunoglobulin heavy chain."],"number":24,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}