{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_2012_0329878_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"152-270-392-139-433","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11985,"type":"PATENT","title":"University College Dublin Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":879,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8550,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:univ* AND dublin. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 741
Search Applicants and Owners separately:univ* AND dublin. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 741
b) detecting the presence of an immune signature of poor outcome comprising CD8lo,CD68hi or an immune signature of favorable outcome comprising CD8hi,CD68lo in said sample, wherein said immune signature of poor outcome is associated with an increased risk of poor clinical outcome as compared to said immune signature of favorable outcome, and wherein said biomarkers do not comprise CD4."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said poor clinical outcome comprises a relative reduction in one or more of overall survival, recurrence-free survival, and distant recurrence-free survival."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising:\n
c) treating said patient with an aggressive treatment regimen when said immune signature of poor outcome is detected."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said favorable clinical outcome comprises a relative increase in one or more of overall survival, recurrence-free survival, and distant recurrence-free survival."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising:\n
c) treating said patient with a conservative treatment regimen when said immune signature of favorable outcome is detected."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising:\n
a step before a) of obtaining said sample from said patient."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said sample is said breast cancer sample of a subtype selected from the group consisting of Her2+ and basal."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said sample is said epithelial ovarian cancer sample of a serous subtype."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said nucleic acid-based technique comprises reverse transcriptase-polymerase chain reaction."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said nucleic acid-based technique comprises gene expression array."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A method for assessing risk of poor clinical outcome for a human cancer patient, said method comprising:\n
a) subjecting a sample from a solid tumor of said patient to a procedure for quantitation of expression of leukocyte biomarkers comprising CD8 and CD68;\n
b) detecting the presence of an immune signature of poor outcome comprising CD8lo,CD68hi or an immune signature of favorable outcome comprising CD8hi,CD68lo in said sample, wherein said immune signature of poor outcome is associated with an increased risk of poor clinical outcome as compared to said immune signature of favorable outcome, and wherein said biomarkers do not comprise CD4."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["A method for assessing risk of poor clinical outcome for a human cancer patient, said method comprising:\n
a) subjecting a breast cancer sample or an epithelial ovarian cancer sample from said patient to an antibody-based technique for quantitation of expression of leukocyte biomarkers comprising CD4, CD8 and CD68;\n
b) detecting the presence of an immune signature of poor outcome comprising CD4hi,CD8lo,CD68hi or an immune signature of favorable outcome comprising CD4lo,CD8hi,CD68lo in said sample, wherein said immune signature of poor outcome is associated with an increased risk of poor clinical outcome as compared to said immune signature of favorable outcome."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein said poor clinical outcome comprises a relative reduction in one or more of overall survival, recurrence-free survival, and distant recurrence-free survival."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, further comprising:\n
c) treating said patient with an aggressive treatment regimen when said immune signature of poor outcome is detected."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein said favorable clinical outcome comprises a relative increase in one or more of overall survival, recurrence-free survival, and distant recurrence-free survival."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, further comprising:\n
c) treating said patient with a conservative treatment regimen when said immune signature of favorable outcome is detected."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, further comprising:\n
a step before a) of obtaining said sample from said patient."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein said sample is said breast cancer."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein said sample is said epithelial ovarian cancer sample of a serous subtype."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein said antibody-based technique comprises immunohistochemistry."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, further comprising:\n
detecting metastasis to a regional or a draining lymph node of the human cancer patient."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["A method for assessing risk of poor clinical outcome for a human cancer patient, said method comprising:\n
a) subjecting a sample from a solid tumor of said patient to a procedure for quantitation of expression of leukocyte biomarkers comprising CD4, CD8 and CD68;\n
b) detecting the presence of an immune signature of poor outcome comprising CD4hi,CD8lo,CD68hi or an immune signature of favorable outcome comprising CD4lo,CD8hi,CD68lo in said sample, wherein said immune signature of poor outcome is associated with an increased risk of poor clinical outcome as compared to said immune signature of favorable outcome."],"number":22,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}