{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_2012_0040004_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"162-748-948-766-735"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10800,"type":"PATENT","title":"Aarhus University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1140,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8265,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Aarhus Univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 786
Search Applicants and Owners separately: \"Aarhus Univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 786
providing a TNF-alpha antagonist to a subject in need thereof; and\n
evaluating fibrosis in said subject after providing said TNF-alpha antagonist."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["2-10. (canceled)"],"number":-1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the TNF-alpha antagonist interacts with the mRNA encoding TNF-alpha or binds directly to TNF-alpha and said TNF-alpha antagonist is selected from the group consisting of an siRNA specific for an mRNA encoding TNF-alpha, an antibody, an aptamer, a soluble TNF-alpha receptor, or an RNase H inducing antisense oligonucleotide specific for an mRNA encoding TNF-alpha, and a ribozyme specific for an mRNA encoding TNF-alpha."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said TNF-alpha antagonist is an siRNA."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 12, wherein said siRNA is present in a chitosan/siRNA nanoparticle."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein said TNF-alpha antagonist is formulated for intraperitoneal administration."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said TNF-alpha antagonist is provided prior to initiation of radiation therapy."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16, wherein said TNF-alpha antagonist is provided at least 24 hours before radiation therapy."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16, wherein said TNF-alpha antagonist is provided no more than 1 week before radiation therapy."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein repeating cycles of administration of said TNF-alpha antagonist and radiation therapy is performed."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating or preventing radiation induced fibrosis, comprising:\n
providing a TNF-alpha antagonist to a subject in need thereof, wherein said TNF-alpha antagonist is a chitosan/siRNA nanoparticle and, wherein said siRNA is specific for an mRNA encoding TNF-alpha; and\n
evaluating fibrosis in said subject after providing said TNF-alpha antagonist."],"number":19,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}