US 2011/0046154 A1 - Use Of Aminopeptidase Inhibitors Or Azaindole Compounds For Preventing Or Treating Cancerous Metastases From Epithelial Origin - The Lens - Free & Open Patent and Scholarly Search

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US 2011/0046154 A1

Abstract

The invention relates to the use of a compound selected from an aminopeptidase-inhibiting compound and an azaindole compound for producing a drug for preventing or treating cancerous metastases in humans or animals.

Claims

1-10. (canceled)
A method for the prevention or treatment of cancerous metastases in humans or animals consisting in administering a compound selected from an aminopeptidase inhibitor compound and an azaindole compound.
The method of claim 11, wherein the aminopeptidase inhibitor compound is the compound of formula (I) below:
The method of claim 11, wherein the azaindole compound is the compound of formula (II) below:
in which the group R1 is a linear or branched alkyl having from 1 to 6 carbon atoms.
The method of claim 11, wherein the azaindole compound is the compound of formula (III) below:
in which the groups R1, R2, R3, and R4 each represent, independently of one another, an alkyl of 1 to 6 carbon atoms.
The method of claim 11, wherein the azaindole compound is the compound of formula (IV) below: in which the groups R1, R2, and R3 each represent, independently of one another, a halogen selected from F, Cl, I, and Br.
The method of claim 11, wherein the azaindole compound is the compound of formula (V) below:
in which:

the group R1 is a halogen selected from F, Cl, I, and Br, and

the group R2 is a linear or branched alkyl having from 1 to 6 carbon atoms.
The method of claim 11, wherein the azaindole compound is the compound of formula (VI) below:
in which the group R1 is a halogen selected from F, Cl, I, and Br.
The method of claim 11, wherein the azaindole compound is selected from the following compounds:
methyl 4-[([3-(4-fluorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)benzoate;

3,4,5-triethoxy-N-(2-methyl-4-nitrophenyl)benzamide;

5-(5-bromo-3-chloro-2-hydroxybenzylidene)-1-(4-chlorophenyl)-2,4,6-(1H,3H,5H)pyrimidinetrione;

5-bromo-N-(4-butoxyphenyl)nicotinamide; and

3-chloro-1-phenyl-4-[(2-phenylethyl)amino]-1H-pyrrole-2,5-dione.
The method of claim 11, wherein said medicament is intended for the prevention or treatment of epithelial cancers.
The method of claim 19, wherein the epithelial cancer is selected from a colorectal cancer and a breast cancer.

Owners (US)

Centre National De La Recherche Scientifique (Aug 30 2010)
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Applicants

Centre Nat Rech Scient
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Inventors

Roux Pierre
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De Toledo Marion
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Leonetti Jean-paul
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Anguille Christelle
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CPC Classifications

A61K31/167
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A61K31/402
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A61K31/4174
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A61K31/437
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A61K31/455
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A61K31/513
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A61K31/517
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IPC Classifications

A61K31/136
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A61K31/4164
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A61K31/426
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A61K31/44
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A61K31/497
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A61K31/505
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A61K31/517
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A61P35/00
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US Classifications

514/254.03
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514/266.31
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514/274
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514/355
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514/365
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514/391
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514/646
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Document History

Publication: Feb 24, 2011
US 2011/0046154 A1
Application: Jan 21, 2009
US 81250109 A
Priority: Jan 21, 2009
FR 2009050081 W
Priority: Jan 22, 2008
FR 0850389 A