Leukemic Cell Cns Infiltration Controlled By Notch-induced Chemotaxis

Abstract

The present invention is directed to methods of preventing central nervous system leukemia, treating T-cell acute lymphoblastic leukemia, and treating immune system disorders associated with CCR7-CCL19 mediated signaling. Suitable therapeutic agents for inhibiting CCR7-CCL19 signaling and methods of identifying additional therapeutic agents useful in the methods of the present invention are also disclosed.


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Document History
  • Publication: Nov 11, 2010
  • Application: May 10, 2010
    US US 77692010 A
  • Priority: May 10, 2010
    US US 77692010 A
  • Priority: May 8, 2009
    US US 17671309 P

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