{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_2010_0069420_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"063-760-295-175-26X"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8906,"type":"PATENT","title":"Univ Pennsylvania Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":24238,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8221,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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wherein\n
R1 is hydrogen, alkyl, aralkyl, formamidinyl, aminosulfonyl, or —C(═Y)NH2;\n
a1 is alkylene or a bond;\n
R2 and R3 are each independently C2-C4 alkyl,\n
or,\n
R2 and R3 taken together along with the carbon atom to which they are both attached form a 5- or 6-membered carbocyclic or heterocyclic ring, and R2 and R3 are each independently —CH2—, S, or O;\n
Y is O or S;\n
or a stereoisomer, partial stereoisomer, prodrug, pharmaceutically acceptable salt, hydrate, solvate, acid hydrate, or N-oxide thereof."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1 wherein said influenza A virus-affected disease state or infection comprises influenza (flu)."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1 wherein said influenza A virus-affected disease state or infection comprises one or more of pneumonia, bronchitis, sinus infection, and ear infection."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1 said composition additionally comprises a pharmaceutically acceptable carrier, diluent, or excipient."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1 wherein said influenza A virus is a wild-type virus."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1 wherein said influenza A virus is a mutant."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein R2 and R3 taken together along with the carbon atom to which they are both attached form cyclohexane."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 7 wherein R1 is aralkyl."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 8 wherein R1 is —CH2-aryl."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 9 wherein R1 is —CH2-cyclopropyl, —CH2-cyclopentyl, —CH2-(3-thiopheneyl), —CH2-(1-Methyl-1H-pyrazol-4-yl), —CH2-(5-Methyl-isoxazol-3-yl), —CH2-(5-pyridinyl), —CH2-(5-1H-imidazolyl), or —CH2-(2-1H-imidazolyl)."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein R1 is hydrogen, and R2 and R3 are each C2-C4 alkyl."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["A compound having the formula (I):\n
wherein\n
R1 is hydrogen or aralkyl;\n
R2 and R3 are each independently C2-C4 alkyl;\n
or,\n
R2 and R3 taken together along with the carbon atom to which they are both attached form a 6-membered carbocyclic ring;\n
or a stereoisomer, partial stereoisomer, prodrug, pharmaceutically acceptable salt, hydrate, solvate, acid hydrate, or N-oxide thereof."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 12 wherein R2 and R3 taken together along with the carbon atom to which they are both attached form cyclohexane."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 13 wherein R1 is aralkyl."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 14 wherein R1 is —CH2-aryl."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 15 wherein R1 is —CH2-cyclopropyl, —CH2-cyclopentyl, —CH2-(3-thiopheneyl), —CH2-(1-Methyl-1H-pyrazol-4-yl), —CH2-(5-Methyl-isoxazol-3-yl), —CH2-(5-pyridinyl), —CH2-(5-1H-imidazolyl), or —CH2-(2-1H-imidazolyl)."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 12 wherein R1 is hydrogen, and R2 and R3 are each C2-C4 alkyl."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A composition comprising a compound according to claim 12 and a pharmaceutically acceptable carrier, diluent, or excipient."],"number":18,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}