{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_2009_0048265_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"165-999-197-304-016","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10795,"type":"PATENT","title":"The Ohio State University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7061,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8260,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"ohio state univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 5396
Search Applicants and Owners separately: \"ohio state univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 5396
R1 and R2 are the same or different and are chosen from H, alkyl, and alkenyl;\n
R3 is chosen from C and S; wherein if R3 is C, then R4 is nothing and if R3 is S, then R4 is ═O;\n
R5 comprises an aryl group chosen, from furyl, pyrrolyl, pyridyl, thiazolyl, oxazolyl, isoxazolyl, imidazolyl, pyrazolyl, pyrimidinyl, thiadiazolyl, oxadiazolyl, quinolyl, isoquinolyl, naphthyl, and phenyl, any of which may be substituted or unsubstituted; and\n
R6 and R7 are i) the same or different and chosen from, H, alkyl, and alkenyl, or are ii) both —CH2— and are bonded together to form a piperazinyl ring;\n
with the proviso that if R1 and R2 are both methyl, R3 is C, and R6 and R7 are both —CH2— and are bonded together to form a piperazinyl ring, then R5 is not 2,3-dihydro-benzo[1,4]dioxane."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 1, wherein R6 and R7 are both —CH2— and are bonded together to form a piperazinyl ring."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 2, wherein R1 and R2 are the same and are alkyl groups."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 3, wherein the alkyl groups are methyl groups."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 4, wherein R3 is C."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 5, wherein R5 is chosen from 2,3-dihydrobenzo[1,4]dioxane, 4-chlorophenyl, 4-cyanophenyl, benzyloxy, 3-cyanophenyl, 4-nitrophenyl, 3,4-dimethoxyphenyl, 1-naphthyl, 4-aminophenyl, 4-t-butylphenyl, and 4-(trifluoromethyl)phenyl."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 4, wherein R3 is S and R4 is ═O."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 7, wherein R5 is chosen from 4-chlorophenyl, 4-bromophenyl, 4-iodophenyl, 5-chlorothienyl, 2-nitrophenyl, 3-nitrophenyl, 4-nitrophenyl, 4-methylphenyl, 4-(trifluoromethyl)-phenyl, 4-methoxyphenyl, 4-(trifluoromethoxy)-phenyl, 4-(methylsulfonyl)-phenyl, 4-t-butylphenyl, 3-carboxyphenyl, 4-carboxyphenyl, 2,5-dichlorophenyl, 2,4-diaminophenyl, 3-carboxy-4-chloro-5-fluorophenyl, 3-carboxy-4,6-dichloro-phenyl, 1-naphthyl, 2-naphthyl, 1-(5-dimethylamino)-naphthyl, biphenyl, 2,4,6-tri-isopropyl-phenyl, and 4-(phenanthren-9-yl)phenyl."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 7, wherein R5 comprises a substituted or unsubstituted biphenyl."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 9, wherein R5 is chosen from 4′-methyl-biphenyl, 4′-trifluoromethyl-biphenyl, 4′-methylsulfonyl-biphenyl, 4′-n-butyl-biphenyl, and 4′-t-butyl-biphenyl."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 2, wherein R3 is S and R4 is ═O."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 11, wherein R5 is an unsubstituted biphenyl."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 12, wherein R1 and R2 comprise groups chosen from methyl, ethyl, propyl, butyl, methylene, ethylene, propylene, and butylene."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 13, wherein R1 and R2 are the same and are chosen from allyl, n-propyl, isopropyl, and n-butyl."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 1, wherein R6 and R7 are H."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 15, wherein R1 and R2 are the same and are alkyl groups."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 16, wherein the alkyl groups are methyl groups."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 17, wherein R3 is S and R4 is ═O."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 18, wherein R5 is chosen from 4-t-butyl-benzene and biphenyl."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 1, wherein the compound is an ester or salt."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising the compound according to claim 1, and at least one pharmaceutically acceptable excipient."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["A method of inhibiting neoplastic cell proliferation in an animal comprising administering a therapeutically effective amount of at least one compound according to claim 1."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 22, wherein the animal is a human."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["A method of treating cancer in a human in need of such treatment comprising administering a therapeutically effective amount of at least one compound according to claim 1."],"number":24,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}