{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_2009_0028901_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"061-669-064-178-850"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11620,"type":"PATENT","title":"Icahn School of Medicine at Mount Sinai - Patent Portfoilo","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3154,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8295,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: Icalh* medici*
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Select all patents in the collection and expand by simple families. Add to collection. Total patents: 896
Search Applicants and Owners separately: Icalh* medici*
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Select all patents in the collection and expand by simple families. Add to collection. Total patents: 896
(a) infecting cells engineered to express a heterologous viral interferon antagonist with said virus; and\n
(b) culturing the infected cells under conditions that are suitable for propagation of said virus."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein said RNA virus is a segmented negative strand RNA virus."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein said RNA virus is a non-segmented negative strand RNA virus."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein said RNA virus is an influenza virus mutant with a mutation in the genomic segment that encodes NS1."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14, wherein the influenza virus mutant is a delNS1 mutant influenza virus."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein said heterologous viral interferon antagonist is the NS1 protein of an influenza virus."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16, wherein said NS1 protein is the NS1 protein of an influenza A virus."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16, wherein said NS1 protein is the NS1 protein of an influenza B virus."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16, wherein said NS1 protein is the NS1 protein of an influenza C virus."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein said heterologous viral interferon antagonist is the VP35 protein of Ebola virus, the NS2 protein of respiratory syncytial virus (RSV), the E3L protein of vaccinia virus or the ICP34.5 protein of herpes simplex virus type I (HSV-I)."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["A method for vaccine production comprising:\n
(a) propagating an attenuated negative strand RNA virus with an impaired ability to antagonize a cellular interferon response in cells that express a heterologous viral interferon antagonist; and\n
(b) collecting progeny virus, wherein said virus is grown under conditions and to sufficient quantities so that the progeny virus is suitable for formulation into a vaccine."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 21, wherein said RNA virus is a segmented negative strand RNA virus."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 21, wherein said RNA virus is a non-segmented negative strand RNS virus."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 21, wherein said attenuated negative strand RNA virus is an influenza virus mutant with a mutation in the genomic segment that encodes NS1."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 24, wherein said influenza virus mutant is a delNS1 mutant influenza virus."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 21, wherein said heterologous viral interferon antagonist is the NS1 protein of an influenza virus."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 26, wherein said NS1 protein is the NS1 protein of an influenza A virus."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 26, wherein said NS1 protein is the NS1 protein of an influenza B virus."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 26, wherein said NS1 protein is the NS1 protein of an influenza C virus."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 21, wherein said heterologous viral interferon antagonist is the VP35 protein of Ebola virus, the NS2 protein of RSV, the E3L protein of vaccinia virus, or the ICP34.5 protein of HSV-I."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["A cell infected with an attenuated negative strand RNA virus with an impaired ability to antagonize a cellular interferon response, wherein the cell recombinantly expresses a heterologous viral interferon antagonist."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 31, wherein said RNA virus is a segmented negative strand RNA virus."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 31, wherein said RNA virus is a non-segmented negative strand RNA virus."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 31, wherein said RNA virus is an influenza virus mutant with a mutation in the genomic segment that encodes NS1."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 34, wherein said influenza virus mutant is a delNS1 mutant influenza virus."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 31, wherein said cell is a MDCK cell."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 31, wherein said cell is a human embryonic kidney cell, human osteogenic sarcoma cell, HeLa cell, Cos cell, or NIH3T3 cell."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 31, wherein said heterologous viral interferon antagonist is the NS1 protein of an influenza virus."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 38, wherein said NS1 protein is the NS1 protein of an influenza A virus."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 38, wherein said NS1 protein is the NS1 protein of an influenza B virus."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 38, wherein said NS1 protein is the NS1 protein of an influenza C virus."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The cell of claim 37, wherein said heterologous viral interferon antagonist is the VP35 protein of Ebola virus, the NS2 protein of RSV, the E3L protein of vaccinia virus or the ICP34.5 protein of HSV-I."],"number":42,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}