{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_2009_0022656_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"053-972-002-609-098","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11703,"type":"PATENT","title":"Tel Aviv University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":6197,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8357,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: tel aviv uni*
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Search Applicants and Owners separately: tel aviv uni*
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Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 4719
(a) dissolving a glycoprotein;\n
(b) providing a reaction vessel in which a lipid is disposed in a thin layer;\n
(c) buffering the lipid to a basic pH;\n
(d) admixing the dissolved glycoprotein in the reaction vessel;\n
(e) adding a crosslinker, and optionally adding a bioactive agent stable at a basic pH;\n
(f) incubating the glycoprotein and lipid and cross-linker reaction mixture, with continuous shaking, for an amount of time and under temperature conditions sufficient for lipidated glycoprotein disks to form;\n
(g) buffering a resultant lipidated glycoprotein disk to a neutral pH;\n
(h) separating unbound glycoprotein by centrifugation; and\n
(i) lyophilizing the resultant lipidated glycoprotein disk to produce lipidated glycoprotein microparticles."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 10, wherein the lipid is phosphatidylethanolamine."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 10, wherein the glycoprotein is collagen."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 10, wherein the basic pH is in a pH range of 8-10."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 10, wherein the cross-linker is glutaraldehyde."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 10, wherein the amount of time and temperature conditions sufficient for disks to form is overnight at 4° C."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 10, further comprising the step of forming microparticles by means of the application of mechanical forces to crush the lipidated glycoprotein disks into particles."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 10, wherein the lipidated glycoprotein disks have a biologically active ingredient entrapped therein, and wherein the lyophilized glycoprotein disks are reconstituted in water, and a powdered biologically active ingredient is added, whereby the active ingredient is entrapped within the lipidated glycoprotein disks."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 17, comprising the steps of reconstituting lyophilized microparticles in water, and adding a powdered active ingredient, whereby the active ingredient is entrapped within the microparticles."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["A method for treating an animal suffering from a pathological condition, comprising administering to the animal in need thereof an effective amount of the lipidated glycoprotein microparticles or macroparticles of claim 5, wherein the pathological condition is selected from the group consisting of cancer, bacterial infections, fungal infections, viral infections, parasite infections, prion infections, osteoarthritis, and osteomyelitis."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["A method in accordance with claim 19, wherein the pathological condition is cancer and the bioactive agent is an anticancer drug."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["A method in accordance with claim 19, wherein the pathological condition is a bacterial infection and the bioactive agent is an antibacterial drug."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 21, wherein the bacterial infection is osteomyelitis."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["A method in accordance with claim 19, wherein the pathological condition is a fungal infection and the bioactive agent is an antifungal drug."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["A method in accordance with claim 19, wherein the pathological condition is a viral infection and the bioactive agent is an antiviral drug."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["A method in accordance with claim 19, wherein the pathological condition is a parasitic infection and the bioactive agent is an antiparasite drug."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["A method in accordance with claim 19, wherein the pathological condition is a prion infection and the bioactive agent is a bioactive agent suitable for treating prion infections."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["A method in accordance with claim 19, wherein the pathological condition is osteoarthritis and the bioactive agent is a anti-inflammatory agent suitable for treating osteoarthritis."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["A method of diagnostic imaging of cancer cells in a patient, comprising:\n
administering the lipidated glycoprotein microparticles or macroparticles of claim 1 encapsulating a marker used in imaging, and\n
imaging to detect the presence of cancer cells in the patient."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 28, wherein the marker is a radioactive isotope."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 29, wherein the radioactive isotope is selected from the group consisting of 99mTc, 127I, and 67Gd."],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 30, wherein the marker is a fluorescent molecule."],"number":31,"annotation":false,"claim":true,"title":false},{"lines":["In a method of diagnostic imaging of cancer cells, comprising the steps of administering a diagnostic agent to a patient and imaging the patient to detect the presence and/or location of the diagnostic agent, the improvement wherein the diagnostic agent is lipidated glycoprotein microparticles or macroparticles in accordance with claim 5."],"number":32,"annotation":false,"claim":true,"title":false},{"lines":["In a method of gene delivery and short-term expression of nucleic acids to cancer cells for therapeutic purposes, comprising administering to an animal in need thereof an effective amount of nucleic acids, the improvement wherein the nucleic acids are formulated so as to be encapsulated in the lipidated glycoprotein microparticles or macroparticles in accordance with claim 1."],"number":33,"annotation":false,"claim":true,"title":false},{"lines":["In a method for treating an indication with a drug that is effective for treating said indication, the improvement wherein said drug is administered encapsulated in lipidated glycoprotein microparticles or macroparticles."],"number":34,"annotation":false,"claim":true,"title":false},{"lines":["35-36. (canceled)"],"number":-1,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}