Process For Producing Farnesylated Dibenzodiazepinone By Fermentation

  • Published: Nov 1, 2007
  • Earliest Priority: Apr 14 2006
  • Family: 8
  • Cited Works: 0
  • Cited by: 4
  • Cites: 6
  • Additional Info: Full text
Abstract

The present invention provides a scalable process for producing a concentrate containing a mass of a farnesylated dibenzodiazepinone by fermenting in an aqueous culture medium a strain of a microorganism that is capable of producing the farnesylated dibenzodiazepinone, upon completion of fermentation harvesting the fermentation broth and extracting the fermentation broth to provide an extract, and thereafter treating the extract to form the concentrate. The concentrate so produced may be utilized in downstream processes for producing pharmaceutical compounds. A strain of a Micromonospora species capable of producing a farnesylated dibenzodiazepinone at a high yield rate is provided, together with culture media for culturing microorganisms, and fermentation conditions for production of the farnesylated dibenzodiazepinone of the concentrate.


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Document History
  • Publication: Nov 1, 2007
  • Application: Apr 16, 2007
    US US 78522607 A
  • Priority: Apr 16, 2007
    US US 78522607 A
  • Priority: Apr 14, 2006
    US US 79190306 P

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