Novispirins: Antimicrobial Peptides

文摘(摘要)

Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and were well-tolerated in vivo after intravenous injection. Novispirins also bind lipopolysaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections.


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文档历史记录
  • 公布: 2002-6-27
  • 申请: 2001-4-19
    US US 84000901 A
  • 优先权: 2001-4-19
    US US 84000901 A
  • 优先权: 2000-6-28
    US US 60685800 A

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