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Novispirins: Antimicrobial Peptides

  • تم نشره: 27/06/2002
  • أسرة: 3
  • اقتباسات المقالات المذكورة ببراءات الاختراع: 0
  • مقتبس منها: 13
  • اقتباسات: 0
  • تسلسلات: 37
  • معلومات: نص كامل Published Sequence
نبذة مختصرة

Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and were well-tolerated in vivo after intravenous injection. Novispirins also bind lipopolysaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections.


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  • منشورات: 27/06/2002
  • الطلب: 19/04/2001
    US US 84000901 A
  • الأولوية: 19/04/2001
    US US 84000901 A
  • الأولوية: 28/06/2000
    US US 60685800 A

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