Compositions And Methods For The Treatment Of Tissue Fibrosis

Abstract

Provided are methods of treating tissue fibrosis comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a hyaluron synthase (HAS) or CD44. Further provided are methods of inhibiting myofibroblast invasion, or of reducing matrix deposition in the lung, the methods comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a HAS or CD44. Further provided are methods of determining the progression of pulmonary fibrosis, the methods comprising determining the level of matrix metalloproteinase expression in a cell, and comparing the level of expression to that of a control cell, wherein an increased level of expression relative to the control cell indicates progression of the disease.


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Owners (US)
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Document History
  • Publication: Mar 19, 2019
  • Application: Apr 12, 2012
    US US 201214111338 A
  • Priority: Apr 12, 2012
    US US 201214111338 A
  • Priority: Apr 12, 2012
    US US 2012/0033246 W
  • Priority: May 15, 2011
    US US 201161486292 P
  • Priority: Apr 12, 2011
    US US 201161474718 P

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