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(1) lysing a first cell of interest from an imaged cluster of cells with a laser, wherein said cluster of cells is located in a containment device configured for flow through of lysate;\n
(2) collecting cellular contents of the lysed cell from said containment device by flowing said lysate to an outlet;\n
(3) performing RT-qPCR on said cellular contents of the lysed cell;\n
(4) repeating steps (1)-(3) with a second cell of interest from said cluster of cells; and\n
(5) constructing a 3D spatial map of said target molecule expression in said first and second cells based on a RT-qPCR result on a respective content of each lysed cell and known coordinates of each cell determined from said imaged cluster of cells."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said target molecule of interest is selected from the group consisting of DNA, RNA, and protein."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said performing RT-qPCR utilizes SQUIRT-PCR."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said lysing utilizes a two-photon (2P) process."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the cell is live, fixed, frozen or preserved."],"number":5,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}