Substituted Quinazoline Compounds And Uses Thereof For Modulating Glucocerebrosidase Activity

  • Published: Jan 1, 2019
  • Earliest Priority: Jul 01 2015
  • Family: 9
  • Cited Works: 34
  • Cited by: 1
  • Cites: 1
  • Additional Info: Cited Works Full text
Abstract

Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules or activated glucocerebrosidase conjugated to the small molecules, which compositions may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease.


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Document History
  • Publication: Jan 1, 2019
  • Application: Jun 30, 2016
    US US 201615199207 A
  • Priority: Jun 30, 2016
    US US 201615199207 A
  • Priority: Jul 1, 2015
    US US 201562187461 P

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