Proteomic Biomarkers Of Sepsis In Elderly Patients

Abstract

A proteomic expression platform to identify age-related sepsis risk is disclosed using patients with community-acquired pneumonia. A semi-quantitative plasma proteomics workflow was applied which incorporated tandem immuno affinity depletion, iTRAQ labeling, strong cation exchange fractionation, and nanoflow-liquid chromatography coupled to high resolution mass spectrometry. A protein profile was determined that exhibit statistically significant differences in expression levels amongst patients with severe sepsis as a function of age. Representative pathways that are differentially-expressed include, but are not limited to, acute phase response, coagulation signaling, atherosclerosis signaling, lipid metabolism, and production of nitric oxide/reactive oxygen species.


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Document History
  • Publication: Nov 13, 2018
  • Application: Jun 24, 2014
    US US 201414392122 A
  • Priority: Jun 24, 2014
    US US 201414392122 A
  • Priority: Jun 24, 2014
    US US 2014/0043909 W
  • Priority: Jun 25, 2013
    US US 201361839214 P

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