{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"EP_3146981_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"017-264-469-857-594"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10774,"type":"PATENT","title":"University of Munich - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1687,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8244,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Ludwig* Maximilian* Univ*\"; \"Ludwig* Maximilian* mun*\"; \"Lud* Maxi* m?n*\"; \"uni* Lud* Maxi*\"
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Search Applicants and Owners separately: \"Ludwig* Maximilian* Univ*\"; \"Ludwig* Maximilian* mun*\"; \"Lud* Maxi* m?n*\"; \"uni* Lud* Maxi*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 216
- a substrate, an inhibitor, a cofactor, an agonist, an antagonist, a modulator of the target protein,
- a ligand of a receptor of interest (such as an agonist, antagonist, inhibitor, blocker or modulator), preferably a ligand of a G-protein coupled receptor (GPCR), an ionotropic receptor and/or a receptor-linked enzymesuch as a glutamate, a tetraalkyl ammonium moiety or other pharmaceutical group, and/or wherein the azobenzene moiety Azo is an azobenzene or a derivative thereof, such as heterocyclic azobenzene structure(s), substituted azobenzene structure(s) (e.g. tetra-ortho), bridged azobenzenes (e.g. by an o,o'-ethylene chain)."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 or 2, wherein the activation/deactivation wavelength is in the ultraviolet, visible and infrared light ranges of the electromagnetic spectrum."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The compound of any one of claims 1 to 3 having the general formula Ia BG - (link)n -Azo - glu (Ia) wherein BG is the benzyl guanine moiety, link is a linker group, preferably polyethylene glycol with n being 0 to 12, Azo is the azobenzene moiety, and glu is a glutamate group."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The compound of any one of claims 1 to 4 having one of the formulas of BGAGn or BGAG12(460) or BGAG12 or L-BGAG12 or BCAG12 or CIAG12 or BGAG or BGAP12 or BGAF12 or BGACh12 preferably BGAG12 or BGAG12(460)."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The compound of any one of claims 1 to 5, comprising further group(s) or moiety(ies), such as
- label (e.g. radioisotopes, MRI responsive groups, IR dyes, fluorophores)
- tag(s) (e.g. antibodies, nanobodies, peptides),
- anchoring group(s) (e.g. GPI), and/or
- other pharmacological units (e.g. fentanyl, GABA, choline, propofol)."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition, comprising
(i) at least one photo-switchable benzylguanine compound according to any one of claims 1 to 6,
(ii) optionally, pharmaceutically acceptable excipient(s) and/or carrier(s),
(iii) optionally, further compound(s)."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A photo-sensor protein, comprising a tag for attaching the photo-switchable azobenzene compound according to any one of claims 1 to 6, and the photo-switchable azobenzene compound according to any one of claims 1 to 6, which has been attached to the protein via said tag."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The photo-sensor protein of claim 8, which is a transmembrane protein or receptor, such as a G protein coupled receptor (GPCR), e.g. a metabotropic glutamate receptor (mGluR2), an ionotropic receptor, ion channel and/or a receptor-linked enzyme, wherein the tag is preferably selected from a SNAP-tag, a CLIP-tag, or a Halo tag, wherein preferably said photo-sensor protein is a SNAP-tagged metabotropic glutamate receptor (SNAP-mGluR2), preferably labeled with BGAG12 or BGAG12(460)."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["Use of the photo-switchable azobenzene compound according to any one of claims 1 to 6 for labeling of target proteins, wherein the target protein is preferably a transmembrane protein or receptor, such as a G protein coupled receptor (GPCR), e.g. a metabotropic glutamate receptor (mGluR2), wherein the target protein comprises a tag for labeling which is preferably selected from a SNAP-tag, a CLIP-tag, or a Halo tag."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The use of claim 10 for labeling of target proteins, in vitro, in intact tissue or in vivo."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The use of a photo-switchable azobenzene compound according to any one of claims 1 to 6 or a photo-sensor protein of claim 8 or 9 as research tool, such as:
- for the diagnosis or restoration of vision, sight disorder(s),
- the elucidation of signaling pathways,
- the mapping of neural circuitry,
- the activation/surpression of immune responses,
- the control of nociception
- the control of insulin release and other hormonal pathways, and/or
- as research tool(s) in general."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The use of claim 12, comprising the use of a further photo-sensor protein (e.g. using a SNAP-tag), such as an orthogonal photo-sensor protein (e.g. using a CLIP-tag) or a maleimide-based photo-sensor protein."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The photo-switchable azobenzene compound of any one of claims 1 to 6 or the pharmaceutical composition of claim 7 or the photo-sensor protein of claim 8 or 9 for use in medicine."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The photo-switchable azobenzene compound of any one of claims 1 to 6 or the pharmaceutical composition of claim 7 or the photo-sensor protein of claim 8 or 9 for use
- in the diagnosis and/or treatment of a sight disorder,
- in the improvement of vision,
- in the improvement of neural disorders,
- in the up-/downregulation of the immune system,
- in the treatment of pain sensation, i.e. nociception, and/or
- in the treatment of hormonal disorders, e.g. diabetes,optionally comprising the orthogonal optical control of two receptors within the same cell."],"number":15,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}