Methods For Treating Conditions Associated With Masp-2 Dependent Complement Activation

Full-text?

The full document isn't yet available to us from the patent office.

Abstract

In one aspect, the disclosure provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (Clq-dependent) pathway component of the immune system intact. In another aspect, the disclosure provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.


Claims

Information currently unavailable.

CPC Classifications

Download Citation


Sign in to the Lens

Feedback