{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"EP_2886661_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"143-861-905-961-050","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10777,"type":"PATENT","title":"Kings College London - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2321,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8247,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Lond* King* Colle*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1680
Search Applicants and Owners separately: \"Lond* King* Colle*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1680
a) analysing the level of expression or the activity or the sequence of OVOL1 including exons, introns, upstream and downstream non-coding regions involved in the regulation of OVOL1 expression in a biological sample from an individual,
b) analysing the level of expression or the activity or the sequence of OVOL1 including exons, introns, upstream and downstream non-coding regions involved in the regulation of OVOL1 expression in a biological sample from a healthy individual,
c) comparing the difference in level of expression or activity or in sequence of OVOL1 including exons, introns, upstream and downstream non-coding regions involved in the regulation of OVOL1 expression to healthy individual
d) the difference of step c) is indicative of acne disease or a predisposition to acne, thus diagnosing acne vulgaris."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["Method for monitoring the progression of acne, comprising the following steps:
a) taking a biological sample from the individual,
b) analysing level of expression or the activity or the sequence of OVOL1 including exons, introns, upstream and downstream non-coding regions involved in the regulation of OVOL1 expression in a sample taken and in which a variation in the expression or activity or in sequence of OVOL1 is an indicator of the progression of acne; progression of acne may be from a predominantly comedonal to a more inflammatory dominated state, it may also mean progression towards specific acne subtypes, like nodulocystic acne or acne conglobata or a progression in the other direction, from a more severe to a less severe form of acne."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["Method for monitoring the efficacy of a treatment intended for treating acne, comprising the following steps:
a) administering the desired treatment to the individual identified as having one or more of the symptoms of acne,
b) taking a biological sample from the individual,
c) analysing the level of expression or the activity or the sequence of OVOL1 including exons, introns, upstream and downstream non-coding regions involved in the regulation of OVOL1 expression, in which a variation in the expression, activity or sequence of this marker is an indicator in the treatment of acne."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["In vitro screening method of OVOL1 activators, comprising determining the capacity of said candidate to activate or up-regulate expression and/or to activate the biological function, including transactivation activity of OVOL1."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["In vitro screening method of OVOL1 activators for the identification of drug candidates, comprising the following steps:
a) Collecting at least one biological sample;
b) Contacting at least one sample or a mixture of samples with one or more drug candidates to be tested;
c) Detecting the expression or biological function of OVOL1 in the biological samples or mixture obtained in b);
d) Selecting drug candidates which are capable of increasing the expression or activating biological function of OVOL1 measured in said samples or mixtures obtained in b) and comparing the levels with a sample not mixed with the drug candidate."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["Use of activators identified by screening methods as defined in claim 6 for the preparation of a composition for treating acne and/or acne associated disorders."],"number":7,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}