{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"EP_2474541_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"006-600-603-468-727"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11852,"type":"PATENT","title":"University of Mainz Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15149,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8464,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:univ* AND Mainz. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1203
Search Applicants and Owners separately:univ* AND Mainz. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1203
a) linear or branched C1-C6-alkyl substituted with one substituent selected from -NHR11, -OH, -SH, -C(O)OH and -S(O)2OH, and optionally further substituted with one, two or three substituents independently selected from -NHR13, -OH, -SR13, -C(O)OH, -S(O)2OH, -C(O)NH2, -NHC(NH)NH2, -NHC(O)NH2, C3-C7-cycloalkyl, phenyl and 5- or 6-membered heteroaryl, said cycloalkyl being optionally substituted with one or two C1-C6-alkyl, and said phenyl and heterocyclyl being optionally substituted with one, two, three or four substituents independently selected from -OH, C1-C6-alkyl and -C(O)OH; or
b) a 5- or 6-membered saturated heterocyclyl, optionally substituted with one, two or three substituents independently selected from C1-C6-alkyl, -OH and -C(O)OH;
c) C1-C6-alkyl substituted with monocyclic or bicyclic heteroaryl, in particular with imidazolyl such as 5-imidazolyl, said aryl being optionally substituted with one, two, three or four substituents independently selected from -OH, C1-C6-alkyl and -C(O)OH;
d) monocyclic or bicyclic aryl, optionally substituted with one, two, three or four substituents independently selected from -OH, C1-C6-alkyl and -C(O)OH;
e) C3-C7-cycloalkyl optionally substituted with one or two C1-C6-alkyl;
f) monocyclic or bicyclic heteroaryl, optionally substituted with one, two, three or four substituents independently selected from -OH, C1-C6-alkyl, and -C(O)OH;
g) C1-C6-alkyl substituted with monocyclic or bicyclic aryl, in particular with phenyl, said aryl being optionally substituted with one, two or three substituents independently selected from -OH, C1-C6-alkyl, and -C(O)OH; and
h) -(CH2CH2O)mH, -(CH(CH3)CH2O)mH, or -(CH2CH(CH3)O)mH, wherein m is 1 to 10; R11 is selected from -H, C1-C6-alkyl, phenyl and benzyl; R12 is -H or C1-C8-alkyl; and R13 is selected from -H, C1-C6-alkyl, phenyl and benzyl; and the physiologically acceptable salts, solvates and solvates of the salts of the compounds of formula I."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of claim 1
(a) having formula la: wherein R1, R7, R8 and R9 are as defined in claim 1 and R4, R5 and R6 are C1-C6-alkoxy;
(b) having formula Ib: wherein R1, R7, R8 and R9 are as defined in claim 1 and R4, R5 and R6 are C1-C6-alkoxy;
(c) having formula Ic: wherein R1, R7, R8 and R9 are as defined in claim 1 and R4, R5 and R6 are C1-C6-alkoxy;
(d) having formula Id: wherein R1, R7, R3 and R9 are as defined in claim 1 and R4, R5 and R6 are C1-C6-alkoxy; or
(e) having formula Ie: wherein R1, R7, R3 and R9 are as defined in claim 1 and R4, R5 and R6 are C1-C6-alkoxy."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of any one of the preceding claims, wherein R1 and R7 are -H, and R9 is -H, C1-C6-alkyl or halogen."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of any one of the preceding claims, wherein R3 is -C1-C8-alkyl-X1-OC(O)-R10, -C1-C8-alkyl-X1-NR11C(O)-R10, -C1-C8-alkyl-X1-C(O)NR11-R10, -C1-C8-alkyl-X1-OC(O)NR11-R10 or -C1-C8-alkyl-X1-NR12C(O)NR12-R10."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of any one of the preceding claims, wherein R10 is selected from
a) linear or branched C1-C6-alkyl substituted with one residue selected from - NHR11, -OH, -SH and -C(O)OH, and optionally further substituted with one, two or three residues independently selected from -NHR13, -OH, -SR13, -C(O)OH, - C(O)NH2, -NHC(NH)NH2, -NHC(O)NH2, phenyl, hydroxyphenyl, indolyl and imidazolyl, said indolyl or imidazolyl being optionally substituted with one, two, three or four substituents independently selected from -OH, C1-C6-alkyl and -C(O)OH;
b) 5- or 6-membered saturated heterocycloalkyl, optionally substituted with one or two substituents independently selected from C1-C6-alkyl, -OH and -C(O)OH; and
c) C1-C6-alkyl substituted with imidazolyl."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of any one of the preceding claims, wherein R10 is 2-(1H-imidazol-5-yl)ethyl, or a residue of an amino acid that is derived from said amino acid by removal of an -COOH, -NH2 or-OH group."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of any one of the preceding claims, wherein the amino acid is selected from isoleucine, alanine, leucine, asparagine, lysine, aspartic acid, methionine, cysteine, phenylalanine, histidine, tryptophan, glutamic acid, threonine, glutamine, glycine, valine, serine, tyrosine, arginine, proline, ornithine and citrulline."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of any one of the preceding claims, wherein said amino acid is an α-amino acid."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of any one of the preceding claims, wherein the residue is derived from said amino acid by removal of the -COOH group comprising the C1 atom of the amino acid."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of any one of the preceding claims, wherein the residue is derived from said amino acid by removal of the -NH2 group from the C2 atom of the amino acid."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of any one of the preceding claims, wherein the absolute stereoconfiguration at the C2 atom of the amino acid is L-configuration."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The compounds of claim 1 having a formula selected from and the physiologically acceptable salts, solvates and solvates of the salts thereof."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising at least one compound of formula I according to any one of claims 1 to 12 and a pharmaceutically acceptable excipient, and, optionally, further comprising an additional chemotherapeutic agent."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 13, wherein the additional chemotherapeutic agent is selected from antineoplastic agents, multidrug resistance reversing agents; and biological response modifiers, and combinations thereof."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A compound of formula I according to any one of claims 1 to 12 for use in treating tumors, optionally further comprising the use of an additional chemotherapeutic agent."],"number":15,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}