Lr-9, Lr-74 And Lr-90 For Use In Treating Complications Resulting From Diabetes


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This invention relates to methods for lowering lipid levels in mammals using compounds that inhibit advanced glycation endproducts (AGEs), LR-9, LR-74 and LR-90. These compounds, which inhibit non-enzymatic protein glycation, also inhibit the formation of advanced lipoxidation endproducts (ALEs) on target proteins by trapping intermediates in glycoxidation and lopoxidation and inhibiting oxidation reactions important in the formation of AGEs and ALEs.


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Document History
  • Publication: Jan 5, 2011
  • Application: Oct 27, 2004
    EP EP 10183235 A
  • Priority: Oct 27, 2004
    EP EP 04796420 A
  • Priority: Oct 27, 2003
    US US 51447603 P

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