{"search_session":{},"preferences":{"l":"ar","queryLanguage":"ar"},"patentId":"EP_2264454_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"192-442-907-997-947","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11782,"type":"PATENT","title":"Maastricht University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":578,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8416,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: Maastricht Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 533
Search Applicants and Owners separately: Maastricht Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 533
a. providing an assay wherein the expression of a pathway can be determined under the influence of a reactive oxygen species,
b. providing a candidate therapeutic compound,
c. determining the ability of said therapeutic compound to normalize the expression of said pathway after exposure to said reactive oxygen species or even in the presence of said reactive oxygen species,wherein said pathway is selected from the group consisting of consisting of Arginine metabolism, Polyamine metabolism, (L)-Arginine metabolism, IAP-proteins in apoptosis, regulation of aminoacid metabolism, WNT signaling pathway, Chromosome condensation in prometaphase, Urea cycle, ECM remodeling, Glucocorticoid receptor signaling, Initiation of mitosis, Aspartate and asparagine metabolism, Role of Akt in , hypoxia induced HIF1 activation, IL-3 activation and signaling pathway, IL-2 activation , and signaling pathway, Activin A signaling regulation, Vitamin B7 (biotin) metabolism, Chromosome condensation in prometaphase, NOTCH1-mediated pathway for NF-KB activity modulation, Start of DNA replication in early S phase, ATM/ATR regulation of G1/S checkpoint, , Leucine, isoleucine and valine metabolism, Role of SCF complex in cell cycle regulation, Propionate metabolism, Sin3 and NuRD in transcription regulation, Brca1 as a transcription regulator, Spindle assembly and chromosome separation, Sister chromatid cohesion, Glutathione metabolism, Notch Signaling Pathway, ESR1 regulation of G1/S transition, P53 signaling pathway, Transition and termination of DNA replication, Heme metabolism, Initiation of mitosis, Triacylglycerol metabolism ,Bile Acid Biosynthesis and Role of Akt in hypoxia induced HIF1 activa."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["Method according to claim 1 wherein the expression of individual genes in the pathway is determined and wherein the ability of the therapeutic compound to normalize the expression of the majority of said genes is determined."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["Method according to claims 1 or 2 wherein step c is conducted at different time points"],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["Method according to claims 1 - 3 wherein the reactive oxygen species is hydrogen peroxide or Menadione."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["Method according to claims 1 - 4 wherein the eukaryotic cells are Caco cells, in particular Caco-2 cells."],"number":5,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}