Transferrin Variants And Conjugates

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Abstract

The application discloses variants of polypeptides of the transferrin family comprising at least on free thiol group on the surface, which polypeptide has reduced binding to at least one of the transferrin receptors. The polypeptides of the invention are useful for preparing conjugates with bioactive and/or therapeutic compounds, which compounds have high stability and long plasma halflife, which make these conjugates particular suitable for treatment of various diseases and disorders.


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Document History
  • Publication: Aug 11, 2010
  • Application: Feb 10, 2009
    EP EP 09001878 A
  • Priority: Feb 10, 2009
    EP EP 09001878 A

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