{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"EP_2186907_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"073-136-335-970-529"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11721,"type":"PATENT","title":"University of Kiel - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":543,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8374,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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a) measuring the expression of at least one of the proteins CYLC1, HDX, POU3F4 and RPS6KA6, preferably RPS6KA6, in cells from a mammal having an immunodeficiency virus-infection, preferably an HIV-infection, or in experimentally immunodeficiency virus-infected cells from a mammal,
b) contacting said protein CYLC1, HDX, POU3F4 and/or RPS6KA6, with at least one potentially interacting compound, and
c) measuring the change of the expression of the protein CYLC1, HDX, POU3F4 and/or RPS6KA6 in the presence of said compound from step b)."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 8, further comprising the steps of:
d) measuring the biological function of the protein CYLC1, HDX, POU3F4 and/or RPS6KA6, and/or the decline of the CD4+ T cell counts and/or viral load in the presence or absence of said binding compound."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 8 or 9, further comprising the step of performing a method according to any of claims 1 to 6."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A method for producing a pharmaceutical composition for the treatment of AIDS and/or AIDS progression, comprising the method according to any of claims 8 to 10, and further comprising the step of admixing said compound changing the expression of the proteins HDX, POU3F4, CYLC1 and/or RPS6KA6 with suitable auxiliary substances and/or additives."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["Pharmaceutical composition for the treatment of AIDS and/or AIDS progression, produced according to claim 11."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A kit, in particular a diagnostic kit comprising materials for performing the method according to any of claims 1 to 10, in particular materials for analysing SNPs in a mammal that are selected from the SNPs rs825541, rs1531868, rs5968255, rs10218349, and/or rs2092545, and preferably rs5968255."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The kit according to claim 13, further comprising materials for analysing the proteins CYLC1, HDX, POU3F4 and/or RPS6KA6, in particular for an antibody-mediated detection or the detection of a modification of said proteins."],"number":14,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}