Multipotent Stem Cells And Uses Thereof

  • Published: Jul 7, 2010
  • Family: 16
  • Cited Works: 6
  • Cited by: 0
  • Cites: 4
  • Additional Info: Cited Works
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Abstract

The invention provides a quiescent stem cell having the capacity to differentiate into ectoderm, mesoderm and endoderm, and which does not express cell surface markers including MHC class I, MHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105 and CD90. The invention further provides a proliferative stem cell, which expresses genes including Oct-4, Nanog, Sox2, GDF3, P16INK4, BMI, Notch, HDAC4, TERT, Rex-1 and TWIST but does not express cell surface markers including MHC class I, MHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105 and CD90. The cells of the invention can be isolated from adult mammals, have embryonic cell characteristics, and can form embryoid bodies. Methods for obtaining the stem cells, as well as methods of treating diseases and differentiated the stem cells, are also provided.


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Document History
  • Publication: Jul 7, 2010
  • Application: May 5, 2008
    EP EP 08767550 A
  • Priority: May 5, 2008
    US US 2008/0005742 W
  • Priority: May 3, 2007
    US US 92759607 P

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