Serine Proteases With Altered Sensitivity To Activity-modulating Substances

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Abstract

The present invention provides variants of serine proteases of the S1 class with altered sensitivity to one or more activity-modulating substances. A method for the generation of such proteases is disclosed, comprising the provision of a protease library encoding polynucleotide sequences, expression of the enzymes, screening of the library in the presence of one or several activity-modulating substances, selection of variants with altered sensitivity to one or several activity-modulating substances and isolation of those polynucleotide sequences that encode for the selected variants.


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Document History
  • Publication: Apr 8, 2009
  • Application: May 26, 2006
    EP EP 09150549 A
  • Priority: May 26, 2006
    EP EP 06763303 A
  • Priority: May 26, 2006
    EP EP 09150549 A
  • Priority: May 27, 2005
    EP EP 05104543 A

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