{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"EP_1997822_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"083-277-883-527-976"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[],"notes":[],"inventorships":[],"privateCollections":[],"publicCollections":[],"privateNotes":[],"landscapeCollections":[],"landscapeNotes":[]},"document":{"record_lens_id":"083-277-883-527-976","lens_id":["083-277-883-527-976","179-992-301-131-319"],"doc_key":"EP_1997822_A1_20081203","created":"2016-01-13T10:17:37.999","docdb_id":55327987,"lens_internal":{"earliest_lens_id_created_time":"2016-01-13T10:17:37.999","last_modified":"2024-03-25T23:18:52.31","legacy_pub_key":"EP_1997822_A1","has_doc_lang":true,"has_biblio_lang":true,"has_all_title_lang":true,"has_all_abstract_lang":true,"has_all_claims_lang":true,"has_description_lang":true},"jurisdiction":"EP","doc_number":"1997822","kind":"A1","date_published":"2008-12-03","year_published":2008,"ids":["EP_1997822_A1","083-277-883-527-976","179-992-301-131-319","EP_1997822_A1_20081203","EP","1997822","A1","EP1997822A1","EP1997822","1997822A1"],"lang":"en","publication_type":"PATENT_APPLICATION","application_reference":{"jurisdiction":"EP","doc_number":"08013602","kind":"A","date":"2006-11-10"},"priority_claim":[{"jurisdiction":"EP","doc_number":"06808805","kind":"A","date":"2006-11-10"},{"jurisdiction":"HU","doc_number":"P0501046","kind":"A","date":"2005-11-11"}],"priority_claim.source":"DOCDB","earliest_priority_claim_date":"2005-11-11","title":{"de":[{"text":"Verfahren 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for invention","granted":false,"earliest_filing_date":"2006-11-10","application_expiry_date":"2010-01-14","has_disclaimer":false,"patent_status":"DISCONTINUED","publication_count":1,"has_spc":false,"has_grant_event":false,"has_entry_into_national_phase":false},"abstract":{"en":[{"text":"The invention encompasses new 2-methyl-4-(4-methylpiperazin-1--yl)-10H-thieno[2,3-b] [1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB)\n \nthe preparation thereof and pharmaceutical compositions comprising said new compound.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"}]},"abstract_lang":["en"],"has_abstract":true,"claim":{"en":[{"text":"A process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB),\n \nwhich comprises reacting 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b] [1,5]benzodiazepine of the formula (IA) with hydrogen chloride in an aqueous ethanol medium.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"A process as claimed in claim 1, which comprises carrying out the reaction in a 8:2 mixture by volume of ethanol and water.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"A process as claimed in claim 1, which comprises carrying out the reaction in a 9:1 mixture by volume of ethanol and water.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"A process as claimed in claim 1, which comprises adding an aqueous hydrogen chloride solution to a suspension of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine of the formula (IA) in ethanol.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"A process as claimed in claim 4, which comprises using 37% aqueous hydrogen chloride solution.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"A process as claimed in any of claims 1 to 5, which comprises carrying out the reaction at a temperature between 20 °C and 50 °C, preferably at a temperature of 25 °C.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b]-[1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB).","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) as claimed in claim 7, characterized by the X-ray powder diffraction pattern measured using CuK α radiation corresponding to diagram 1 and expressed in the following Table:\n TABLE-tabl0002 Position of diffraction lines and relative intensities (>5%) Peak 2*th D(hkl) I(abs) I(rel) No. [deg] [L] [cps] [%] 1 7.78 11,3638 219 8.74 2 8.17 10.8222 124 4.95 3 8.79 10.0557 2505 100.00 4 11.26 7.8611 143 5.71 5 15.54 5.7012 265 10.58 6 16.28 5.4444 478 19.08 7 17.55 5.0524 817 32.61 8 19.78 4.4885 933 37.25 9 22.26 3.9945 153 6.11 10 24.51 3.6315 348 13.89 11 25.75 3.4605 202 8.06 12 25.93 3.4362 131 5.23 13 31.30 2.8580 558 22.28 14 31.53 2.8375 202 8.06 15 32.38 2.7651 145 5.79 16 32.74 2.7355 404 16.13","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"Pharmaceutical compositions comprising as active ingredient 2-methyl-4-(4-methyl-piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) in admixture with inert solid or liquid pharmaceutical carriers and/or auxiliary agents.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"A process for the preparation of a pharmaceutical composition as claimed in claim 9, which comprises admixing 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) with a pharmaceutically acceptable solid or liquid carrier and/or auxiliary agent and bringing the mixture to galenic form.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"Use of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]-benzodiazepine dihydrochloride trihydrate of the formula (IB) for the preparation of pharmaceutical compositions.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"},{"text":"Use of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]-benzodiazepine dihydrochloride trihydrate of the formula (IB) for the preparation of pharmaceutical compositions having antipsychotic activity.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"}]},"claim_lang":["en"],"has_claim":true,"description":{"en":{"text":"Technical field of the invention The present invention relates to a new olanzapine salt hydrate and the preparation thereof. The invention also relates to pharmaceutical compositions containing said new olanzapine salt hydrate and the use thereof for the preparation of medicaments for the treatment of psychotic conditions. It is known that 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b] [1,5]benzodiazepine of the formula (IA)\n \n(hereinafter referred to as \"olanzapine\") is a valuable antipsychotic drug. International patent application WO 2004/094433 Al provides two new polymorphic forms of olanzapine dihydrochloride, furthermore a new polymorphic olanzapine monohydrochloride. Details of the invention The problem underlying to the invention is to obtain olanzapine in a particularly pure form and with superior filtration, drying and storing characteristics. This has been solved by the invention. According to the present invention there is provided for a process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB),\n \nwhich comprises reacting 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine of the formula (IA) in an aqueous ethanol medium with hydrogen chloride. The reaction can preferably be carried out in an 8:2 mixture, particularly preferably in a 9:1 mixture of ethanol and water. One can also proceed by adding an aqueous hydrogen chloride solution to the suspension of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine of the formula (IA) in ethanol. Preferably 37 % aqueous hydrogen chloride solution is applied. The above process enables the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) in a purity as high as 99.9 % by HPLC in a yield as excellent as 83.5 %. According to a further aspect of the present invention there is provided for the new 2-methyl-4-(4-methylpiperazin-l-yl)-10H-thieno[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB). The X-ray powder diffraction pattern of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b] [1,5] -benzodiazepine dihydrochloride trihydrate of the formula (II) measured by using CuK α radiation corresponds to diagram 1 and can be characterized by the X-ray powder diffraction pattern expressed below:\n TABLE-tabl0001 Position of diffraction lines and relative intensities (>5%) Peak 2*th D(hkl) I(abs) I(rel) No. [deg] [L] [cps] [%] 1 7.78 11.3638 219 8.74 2 8.17 10.8222 124 4.95 3 8.79 10.0557 2505 100.00 4 11.26 7.8611 143 5.71 5 15.54 5.7012 265 10.58 6 16.28 5.4444 478 19.08 7 17.55 5.0524 817 32.61 8 19.78 4.4885 933 37.25 9 22.26 3.9945 153 6.11 10 24.51 3.6315 348 13.89 11 25.75 3.4605 202 8.06 12 25.93 3.4362 131 5.23 13 31.30 2.8580 558 22.28 14 31.53 2.8375 202 8.06 15 32.38 2.7651 145 5.79 16 32.74 2.7355 404 16.13 The above data were determined under the following conditions:\n Equipment:\n PHILIPS - XPERT PW 3710 powder diffractometer Radiation: Cu Kα (λ: 1.54190 L) Monochromator: graphite Excitation voltage: 40 kV Anode current: 30 mA Method:\n Standard reference substance: SRM 675 Mica Powder (synthetic fluorophlogopite), serial number: 981307. The measurement was continuous: Θ/2Θ scan: 4.5°-35.00° 2Θ Step size: 0.02-0.04° Sample: surface plain, width 0.5 mm, in quartz sample holder, measured and stored at room temperature. 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]-benzodiazepine dihydrochloride trihydrate (olanzapine dihydrochloride trihydrate) of the formula (IB) is a highly advantageous crystalline form. The product is a morphologically uniform, stable substance having excellent filtration, drying and storing characteristics, and its storage does not require special circumstances. According to a further aspect of the present invention there is provided for a pharmaceutical composition comprising as active ingredient 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) in admixture with inert solid or liquid pharmaceutical carriers and/or auxiliary agents. According to a still further aspect of the present invention there is provided for a process for the preparation of a pharmaceutical composition, which comprises admixing 2-methyl-4-(4-methylpiperazin-l-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) with a pharmaceutically acceptable solid or liquid carrier and/or auxiliary agent and bringing the mixture to galenic form. The pharmaceutical compositions according to the invention can be prepared by methods conventionally applied in the pharmaceutical industry. The pharmaceutical compositions according to the invention can be administered orally (e.g. tablets, coated tablets, capsules, pills, solutions, suspensions or emulsions), rectally (e.g. suppositories), parenterally (e.g. intravenously, intraperitoneally, etc.) or transdermally. The pharmaceutical compositions according to the invention may contain usual pharmaceutical carriers and/or auxiliary agents. As carrier magnesium carbonate, magnesium stearate, talc, sucrose, lactose, pectin, dextrin, starch, gelatine, tragacanth, methyl cellulose, sodium carboxymethyl cellulose, low melting wax, cocoa butter etc. can be used. In case of capsules the carrier is generally the wall of the capsule so that no additional carrier is needed. As oral administration form the lozenge and sachet can also be mentioned. Tablets, powders, capsules, pills, sachets and lozenges are solid forms particularly suitable for oral administration. Suppositories may contain low melting waxes (e.g. mixtures of fatty acid triglycerides or cocoa butter) as carrier. Suppositories can be prepared by melting the wax, homogeneously distributing the active ingredient in the melt, pouring the melt homogenous mixture into mould forms of suitable size and form, and allowing the mixture to solidify under cooling. Tablets can be prepared by admixing the active ingredient with suitable carriers in the appropriate ratio and pressing the mixture into tablets of suitable size and form. Powders are prepared by admixing the finely powdered active ingredient with finely powdered carriers. As liquid pharmaceutical compositions optionally sustained release solutions, suspensions and emulsions can be mentioned. Aqueous solutions and aqueous propylene glycol solutions are advantageous. Liquid pharmaceutical compositions suitable for parenteral administration can be preferably prepared in the form of aqueous polyethylene glycol solutions. Aqueous solutions suitable for oral administration can be produced by dissolving the active ingredient in water and adding suitable colouring, aromatizing, stabilizing agents and thickeners. Aqueous suspensions suitable for oral administration can be prepared by suspending the active ingredient in water in presence of a viscous substance (e.g. natural or artificial gums, resins, methyl cellulose, sodium carboxymethyl cellulose or other known suspending agents). Another type of solid pharmaceutical compositions can be converted into liquid compositions immediately before use and administered orally into the organism in liquid form. Solutions, suspensions or emulsions can be mentioned as such liquid forms of administration which contain, in addition to the active ingredient, colouring agents, aromatizing agents, preservatives, buffers, artificial or natural sweeteners, dispersing agents, thickeners, etc. The pharmaceutical compositions of the present invention are preferably prepared in dosage unit form. Such dosage units contain the desired amount of the active ingredient. The dosage units can be put on the market in packages containing discrete amounts of the compositions (e.g. packed tablets, capsules or powders in vials or ampoules). The term \"dosage unit\" relates to the capsules, tablets, lozenges, sachets per se and also to the packaging which contains the suitable number of dosage units. The active ingredient may be released from the pharmaceutical compositions according to the present invention immediately or in a delayed manner. The pharmaceutical compositions according to the present invention usually contain about 0.1 - 100 mg, preferably about 0.5 - 50 mg of active ingredient. According to a still further aspect of the present invention there is provided for the use of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b]-[1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) as a pharmaceutically active ingredient. According to a particular aspect of the present invention there is provided for the use of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b]-[1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) for the preparation of pharmaceutical compositions having antipsychotic activity. The invention involves the following advantages:\n The process provides the preparation of high-purity olanzapine in an excellent yield; the new olanzapine dihydrochloride trihydrate according to the invention is a morphologically uniform crystalline form having excellent filtration, drying and storing characteristics, which can be used to advantage in the pharmaceutical industry. Further details of the present invention are provided in the following examples. Example 1 Olanzapine dihydrochloride trihydrate: (IB) 42.6 g (0.14 mole) of olanzapine base are suspended in a mixture of 680 cm 3 of ethanol and 68 cm 3 of water, and 29.2 cm 3 of 37 % hydrogen chloride are dropped to the suspension under stirring. During the addition of hydrogen chloride the suspension turns into solution, then the yellow crystalline product separates continuously. The mixture is stirred further for 2 hours. The suspension is then filtered, washed twice with 15 cm 3 each of cooled ethanol and dried under an infrared lamp. Thus 51.4 g (83.5 %) of the desired product are obtained. M.p. (Kofler): 201-240 °C (continuous decomposition). \nHPLC: 99.9 %. Example 2 Olanzapine dihydrochloride trihydrate: (IB) To a suspension of 5 g (0.016 mole) of olanzapine base in 80 ml of ethanol 3.3 ml of 37 % hydrogen chloride solution are dropped at a temperature of 25 °C, under vigorous stirring (1.46 g, 0.04 mole) under 2 hours. The mixture is then stirred further for 2 hours at a temperature of 25 °C, to the thus-obtained suspension 16 ml of water are dropped, and the suspension is stirred at a temperature of 25 °C for 24 hours. The thus-obtained yellow crystalline substance is filtered off and dried. Thus 5.8 g (82 %) of the desired compound are obtained. Example 3 Olanzapine dihydrochloride trihydrate: (IB) To a suspension of 5 g (0.016 mole) of olanzapine base in 80 ml of ethanol 3.3 ml of 37 % hydrogen chloride solution (1.46 g, 0.04 mole) are dropped within 2 hours at 25 °C, under vigorous stirring. Then 16 ml of water are added to the mixture. During the addition of water a solution is formed, and in half an hour crystals begin to separate. The suspension is stirred for 24 hours, filtered and dried. Thus 4.2 g (60 %) of the desired compound are obtained.","lang":"en","source":"EPO_FULLTEXT","data_format":"ORIGINAL"}},"description_lang":["en"],"has_description":true,"has_docdb":true,"has_inpadoc":true,"has_full_text":true,"biblio_lang":"en"},"jurisdiction":"EP","collections":[],"usersTags":[],"lensId":"083-277-883-527-976","publicationKey":"EP_1997822_A1","displayKey":"EP 1997822 A1","docAssets":{"lensId":"083-277-883-527-976","pdfUrl":"https://www.lens.org/images/patent/EP/1997822/A1/EP_1997822_A1.pdf","images":[{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/10pc/00000001.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/full/00000001.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/10pc/00000002.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/full/00000002.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/10pc/00000003.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/full/00000003.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/10pc/00000004.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/full/00000004.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/10pc/00000005.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/full/00000005.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/10pc/00000006.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/full/00000006.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/10pc/00000007.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/full/00000007.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/10pc/00000008.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/full/00000008.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/10pc/00000009.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/full/00000009.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/10pc/00000010.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/EP/A1/1997/1997822/image/page/full/00000010.png"}],"fallover":false},"countryName":"EUROPEAN PATENT OFFICE","inventorModel":{"inventors":[{"name":{"value":"KOVANYINE LAX GYOERGYI","valueNormalised":"Kovanyine Lax Gyoergyi"},"inventorship":null},{"name":{"value":"NEMETH GABOR","valueNormalised":"Nemeth Gabor"},"inventorship":null},{"name":{"value":"KRASZNAI GYOERGY","valueNormalised":"Krasznai Gyoergy"},"inventorship":null},{"name":{"value":"MESTERHAZY NORBERT","valueNormalised":"Mesterhazy Norbert"},"inventorship":null},{"name":{"value":"NAGY KALMAN","valueNormalised":"Nagy Kalman"},"inventorship":null},{"name":{"value":"VERECZKEYNE DONATH GYOERGYI","valueNormalised":"Vereczkeyne Donath Gyoergyi"},"inventorship":null},{"name":{"value":"SZENT-KIRALLYI ZSUZANNA","valueNormalised":"Szent-kirallyi Zsuzanna"},"inventorship":null}],"inventorships":[],"unmatchedInventorships":[],"activeUserHasInventorship":false},"simpleFamilyId":203578735,"citesPatentCount":4,"countrySpec":{"countryName":"EUROPEAN PATENT OFFICE","description":"APPLICATION PUBLISHED WITH Search Report","rule":"","docType":"PATENT_APPLICATION"},"pageTitle":"EP 1997822 A1 - Process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10h-thieno-[2,3-b] [1,5] benzodiazepine dihydrochloride trihydrate, 2-methyl-4-(4-methyl-piperazin-1-yl) -10h-thieno[2,3-b] [1,5] benzodiazepine dihydrochloride trihydrate, pharmaceutical compositions comprising it and its use","documentTitle":"Process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10h-thieno-[2,3-b] [1,5] benzodiazepine dihydrochloride trihydrate, 2-methyl-4-(4-methyl-piperazin-1-yl) -10h-thieno[2,3-b] [1,5] benzodiazepine dihydrochloride trihydrate, pharmaceutical compositions comprising it and its use"},"claims":{"source":"xml_claims","claims":[{"lines":["A process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB), which comprises reacting 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b] [1,5]benzodiazepine of the formula (IA) with hydrogen chloride in an aqueous ethanol medium."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["A process as claimed in claim 1, which comprises carrying out the reaction in a 8:2 mixture by volume of ethanol and water."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["A process as claimed in claim 1, which comprises carrying out the reaction in a 9:1 mixture by volume of ethanol and water."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["A process as claimed in claim 1, which comprises adding an aqueous hydrogen chloride solution to a suspension of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine of the formula (IA) in ethanol."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["A process as claimed in claim 4, which comprises using 37% aqueous hydrogen chloride solution."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["A process as claimed in any of claims 1 to 5, which comprises carrying out the reaction at a temperature between 20 °C and 50 °C, preferably at a temperature of 25 °C."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b]-[1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB)."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) as claimed in claim 7, characterized by the X-ray powder diffraction pattern measured using CuKα radiation corresponding to diagram 1 and expressed in the following Table: Position of diffraction lines and relative intensities (>5%) Peak 2*th D(hkl) I(abs) I(rel) No. [deg] [L] [cps] [%] 1 7.78 11,3638 219 8.74 2 8.17 10.8222 124 4.95 3 8.79 10.0557 2505 100.00 4 11.26 7.8611 143 5.71 5 15.54 5.7012 265 10.58 6 16.28 5.4444 478 19.08 7 17.55 5.0524 817 32.61 8 19.78 4.4885 933 37.25 9 22.26 3.9945 153 6.11 10 24.51 3.6315 348 13.89 11 25.75 3.4605 202 8.06 12 25.93 3.4362 131 5.23 13 31.30 2.8580 558 22.28 14 31.53 2.8375 202 8.06 15 32.38 2.7651 145 5.79 16 32.74 2.7355 404 16.13"],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["Pharmaceutical compositions comprising as active ingredient 2-methyl-4-(4-methyl-piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) in admixture with inert solid or liquid pharmaceutical carriers and/or auxiliary agents."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A process for the preparation of a pharmaceutical composition as claimed in claim 9, which comprises admixing 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB) with a pharmaceutically acceptable solid or liquid carrier and/or auxiliary agent and bringing the mixture to galenic form."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["Use of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]-benzodiazepine dihydrochloride trihydrate of the formula (IB) for the preparation of pharmaceutical compositions."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["Use of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]-benzodiazepine dihydrochloride trihydrate of the formula (IB) for the preparation of pharmaceutical compositions having antipsychotic activity."],"number":12,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}