Degradable Clostridial Toxins

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Abstract

The specification discloses modified clostridial toxins comprising a PAR ligand domain, a modified BoNT/A comprising: a) a PAR ligand domain; b) a BoNT/A enzymatic domain; c) a BoNT/A translocation domain; and d) a BoNT/A binding domain; polynucleotide molecules encoding said modified clostridial toxin, and a method of producing a modified BoNT/A."


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