Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides And Method Of Reducing Tnf Alpha Levels

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Abstract

1. A 2,6-dioxopiperidine selected from the group consisting of ( a ) a compound of the formula: in which: one of X and Y is C=O and the other of X and Y ( i ) each of R 1 , R 2 , R 3 , and R 4 , independently of yl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms or ( ii ) one of R 1 , R 2 , R 3 , and R 4 is -NHR 5 and the remaining of R 1 , R 2 , R 3 , and R 4 are hydrogen; R 5 is hydrogen, alkyl of 1 to 8 carbon atoms, or CO-R 7 -CH(R 10 )NR 8 R 9 ; R 6 is hydrogen, alkyl of 1 to 8 carbon atoms, benzo, chloro, or fluoro; R 7 is m -phenylene or p -phenylene or -(C n H 2 n )- in which n has a value of 0 to 4; each of R 8 and R 9 taken independently of the other is hydrogen or alkyl of 1 to 8 carbon atoms, or R 8 and R 9 taken together are tetramethylene, pentamethylene, hexamethylene, or -CH 2 CH 2 XCH 2 CH 2 - in which X is -O-, -S- or -NH-; R 10 is hydrogen, alkyl of 1 to 8 carbon atoms, or phenyl; and ( b ) the acid addition salts of said compounds which contain a nitrogen atom capable of being protonated.


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Document History
  • Publication: Aug 13, 2008
  • Application: May 28, 1998
    EP EP 08009864 A
  • Priority: May 28, 1998
    EP EP 04077432 A
  • Priority: May 28, 1998
    EP EP 98924959 A
  • Priority: May 30, 1997
    US US 4827897 P

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