Antibody Variants With Higher Binding Affinity Compared To Parent Antibodies


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Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.


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Document History
  • Publication: Jul 30, 2008
  • Application: Nov 16, 1999
    EP EP 08000450 A
  • Priority: Nov 16, 1999
    EP EP 99960397 A
  • Priority: Nov 18, 1998
    US US 10894598 P

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