{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"EP_1947106_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"103-129-287-352-048"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11813,"type":"PATENT","title":"University of Aberdeen Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":27926,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8443,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: univ* aberdeen. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1658
Search Applicants and Owners separately: univ* aberdeen. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1658
(a) a polynucleotide having at least a 70% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or 4;
(b) a polynucleotide which is complementary to the polynucleotide of (a);
(c) a polynucleotide having at least a 70% identity to a polynucleotide encoding the same mature polypeptide expressed by the metS gene contained in the Streptococcus pneumoniae of the deposited strain; and
(d) a polynucleotide comprising at least 15 sequential bases of the polynucleotide of (a), (b) or (c)."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The polynucleotide of Claim 1 wherein the polynucleotide is DNA."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The polynucleotide of Claim 1 wherein the polynucleotide is RNA."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The polynucleotide of Claim 2 comprising the nucleic acid sequence set forth in SEQ ID NO: 1 or 3."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The polynucleotide of Claim 2 comprising nucleotide 1 to 1995 set forth in SEQ ID NO:1."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The polynucleotide of Claim 2 which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or 4."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A vector comprising the polynucleotide of Claim 1."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A host cell comprising the vector of Claim 7."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A process for producing a polypeptide comprising: expressing from the host cell of Claim 8 a polypeptide encoded by said DNA."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A process for producing a metS polypeptide or fragment comprising culturing a host of claim 8 under conditions sufficient for the production of said polypeptide or fragment."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A polypeptide comprising an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID NO:2 or 4."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["A polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:2."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["An antibody against the polypeptide of claim 11."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["An antagonist which inhibits the activity or expression of the polypeptide of claim 11."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A method for the treatment of an individual in need of metS polypeptide comprising: administering to the individual a therapeutically effective amount of the polypeptide of claim 11."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["A method for the treatment of an individual having need to inhibit metS polypeptide comprising: administering to the individual a therapeutically effective amount of the antagonist of Claim 14."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["A process for diagnosing a disease related to expression or activity of the polypeptide of claim 11 in an individual comprising:
(a) determining a nucleic acid sequence encoding said polypeptide, and/or
(b) analyzing for the presence or amount of said polypeptide in a sample derived from the individual."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A method for identifying compounds which interact with and inhibit or activate an activity of the polypeptide of claim 11 comprising:
contacting a composition comprising the polypeptide with the compound to be screened under conditions to permit interaction between the compound and the polypeptide to assess the interaction of a compound, such interaction being associated with a second component capable of providing a detectable signal in response to the interaction of the polypeptide with the compound;
and determining whether the compound interacts with and activates or inhibits an activity of the polypetide by detecting the presence or absence of a signal generated from the interaction of the compound with the polypeptide."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["A method for inducing an immunological response in a mammal which comprises inoculating the mammal with metS polypeptide of claim 11, or a fragment or variant thereof, adequate to produce antibody and/or T cell immune response to protect said animal from disease."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["A method of inducing immunological response in a mammal which comprises delivering a nucleic acid vector to direct expression of metS polypeptide of claim 11, or fragment or a variant thereof, for expressing said metS polypeptide, or a fragment or a variant thereof in vivo in order to induce an immunological response to produce antibody and/ or T cell immune response to protect said animal from disease."],"number":20,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}