{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"EP_1824510_B1","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"000-818-822-389-07X","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11868,"type":"PATENT","title":"University of South Carolina - Columbia Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":6717,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8472,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Wake Forest Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2294
Search Applicants and Owners separately:Wake Forest Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2294
(a) a flagellin adjuvant comprising:(i) a flagellin N-terminal constant region; and(ii) a flagellin C-terminal constant region; and
(b) a Yersinia pestis antigen between the N-terminal constant region and the C-terminal constant region, wherein the Yersinia pestis antigen is a Y. pestis F1 antigen and/or a Y. pestis V antigen; and wherein the flagellin N-terminal constant region and/or the flagellin C-terminal constant region of the flagellin adjuvant comprises a TLR5 recognition site and the isolated fusion protein is able to activate the TLR5 pathway."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The fusion protein of claim 1, wherein the flagellin adjuvant comprises a deleted flagellin hypervariable region or the flagellin hypervariable region is absent from the flagellin adjuvant."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The fusion protein of claim 1, wherein the Y. pestis antigen is inserted (i) within the hypervariable region, (ii) between the flagellin N-terminal constant region and the hypervariable region, or (iii) between the flagellin C-terminal constant region and the hypervariable region."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The fusion protein of claim 1, wherein the Yersinia pestis antigen a fusion peptide comprising a Y. pestis F1 antigen and a Y. pestis V antigen."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["A nucleic acid encoding the fusion protein of any of claims 1 to 4."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["A vector comprising the nucleic acid of claim 5."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["An isolated or non-human host cell comprising the nucleic acid of claim 5 or the vector of claim 6."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["A method of making the fusion protein of any of claims 1 to 4, the method comprising culturing the host cell of claim 7 in a culture medium under conditions sufficient for the fusion protein to be produced."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 8, wherein the fusion protein is collected from the host cell or from the culture medium."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["An immunogenic composition comprising the fusion protein of any of claims 1 to 4 in a pharmaceutically acceptable carrier."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["An immunogenic composition for mucosal administration, comprising the fusion protein of any of claims 1 to 4 in a pharmaceutically acceptable carrier."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The immunogenic composition of claim 10 or immunogenic composition for mucosal administration of claim 11, further comprising a second Yersinia pestis antigen not coupled to the flagellin adjuvant."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["Use of the fusion protein of any of claims 1 to 4 or the composition or composition for mucosal administration of any of claims 10 to 12 in the manufacture of a medicament to produce an immune response against Yersinia pestis in a mammalian subject."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["Use of the fusion protein of any of claims 1 to 4 or the composition or composition for mucosal administration of any of claims 10 to 12 in the manufacture of a medicament to protect a mammalian subject against the effects of Yersinia pestis infection."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The use of claim 13 or claim 14, wherein the medicament is intended to be administered intranasally or by inhalation."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The use of claim 13 or claim 14, wherein said subject is a human subject at least 50 years old."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The fusion protein of any of claims 1 to 4 or the composition or composition for mucosal administration of claims 10 to 12 to produce an immune response against Yersinia pestis in a mammalian subject."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The fusion protein of any of claims 1 to 4 or the composition or composition for mucosal administration of any of claims 10 to 12 to protect a mammalian subject against the effects of Yersinia pestis infection."],"number":18,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}