Epothilone Derivatives And Their Synthesis And Use

  • Published: Jan 10, 2007
  • Earliest Priority: Jun 22 1998
  • Family: 49
  • Cited Works: 50
  • Cited by: 0
  • Cites: 5
  • Additional Info: Cited Works Published
Full-text?

The full document isn't yet available to us from the patent office.

Abstract

The invention relates to epothilone analog represented by the formula I wherein (i) R 2 is absent or oxygen; "a" can be either a single or double bond; "b" can be either absent or a single bond; and "c" can be either absent or a single bond, with the proviso that if R 2 is oxygen then "b" and "c" are both a single bond and "a" is a single bond; if R 2 is absent then "b" and "c" are absent and "a" is a double bond; and if "a" is a double bond, then R 2 , "b" and "c" are absent; R 3 is a radical selected from the group consisting of hydrogen; lower alkyl; -CH=CH 2 ; -C‰¡CH; -CH 2 F; -CH 2 CI; -CH 2 -OH; -CH 2 -O-(C 1 -C 6 -alkyl); and -CH 2 -S-(C 1 -C 6 -alkyl); R 4 and R 5 are independently selected from hydrogen, methyl or a protecting group; and R 1 is as defined in the specification, or a salt of a compound of the formula I where a salt-forming group is present. A further aspect of the invention is related to the synthesis of epothilone E. These compounds have inter alia microtubuli depolymerisation inhibiting activity and are e.g. useful against proliferative diseases.


Claims

Information currently unavailable.

IPC Classifications
Download PDF
Document Preview
Document History
  • Publication: Jan 10, 2007
  • Application: Jun 21, 1999
    EP EP 06118853 A
  • Priority: Jun 21, 1999
    EP EP 99931120 A
  • Priority: Jun 22, 1998
    US US 10260298 A

Download Citation


Sign in to the Lens

Feedback