{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"EP_1734050_A2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"060-907-294-914-395"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":12008,"type":"PATENT","title":"University of Saskatchewan Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1932,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8572,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Univ* Saskatchewan. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1939
Search Applicants and Owners separately:Univ* Saskatchewan. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1939
(a) an isolated Streptococcus dysgalactiae GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figure 1A-1B (SEQ ID NO:4);
(b) an isolated Streptococcus agalactiae GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 2A-2B (SEQ ID NO:6);
(c) an isolated Streptococcus uberis GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 3A-3B (SEQ ID NO:8);
(d) an isolated Streptococcus parauberis GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 4A-4B (SEQ ID NO:10);
(e) an isolated Streptococcus iniae GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 5A-5B (SEQ ID NO:12); and
(f) immunogenic fragments of (a), (b), (c), (d) and (e) comprising at least about 5 amino acids."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The isolated GapC protein of claim 1, wherein the protein is a Streptococcus dysgalactiae GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 1A-1B (SEQ ID NO:4)."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The isolated GapC protein of claim 1, wherein the protein is a Streptococcus agalactiae GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 2A-2B (SEQ ID NO:6)."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The isolated GapC protein of claim 1, wherein the protein is a Streptococcus uberis GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 3A-3B (SEQ ID NO:8)."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The isolated GapC protein of claim 1, wherein the protein is a Streptococcus parauberis GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 4A-4B (SEQ ID NO:10)."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The isolated GapC protein of claim 1, wherein the protein is a Streptococcus iniae GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 5A-5B (SEQ ID NO:12)."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["An isolated polynucleotide comprising a coding sequence for an isolated GapC protein according to any of claims 1-6, or complements thereof."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A recombinant vector comprising:
(a) the isolated polynucleotide of claim 7; and
(b) at least one heterologous control element operably linked to said isolated polynucleotide, whereby said coding sequence can be transcribed and translated in a host cell, and at least one of said control elements is heterologous to said coding sequence."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A host cell comprising the recombinant vector of claim 8."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A method for producing a GapC protein, said method comprising culturing the cells of claim 9 under conditions for producing said protein."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A vaccine composition comprising a pharmaceutically acceptable vehicle and a GapC protein, wherein said GapC protein is selected from the group consisting of:
(a) a Streptococcus dysgalactiae GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 1A-1B (SEQ ID NO:4);
(b) a Streptococcus agalactiae GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 2A-2B (SEQ ID NO:6);
(c) a Streptococcus uberis GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 3A-3B (SEQ ID NO:8);
(d) a Streptococcus parauberis GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 4A-4B (SEQ ID NO:10);
(e) a Streptococcus iniae GapC protein comprising the amino acid sequence shown at amino acid positions 1 to 336, inclusive, of Figures 5A-5B (SEQ ID NO:12);
(f) a Streptococcus GapC protein having at least about 70% sequence identity to (a), (b), (c), (d) and (e); and
(g) immunogenic fragments of (a), (b), (c), (d), (e) and (f), said fragments comprising at least about 5 amino acids."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 11, wherein said GapC protein comprises the amino acid sequence of the Streptococcus dysgalactiae GapC protein depicted at amino acid positions 1 to 336, inclusive, of Figures 1A-1B (SEQ ID NO:4) or an immunogenic fragment thereof, said fragment comprising at least about 5 amino acids."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 12, wherein said GapC protein comprises the amino acid sequence depicted at amino acid position 1 to 336, inclusive, of Figures 1A-1B (SEQ ID NO:4)."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 11, wherein said GapC protein comprises the amino acid sequence of the Streptococcus agalactiae GapC protein depicted at amino acid positions 1 to 336, inclusive, of Figures 2A-2B (SEQ ID NO:6) or an immunogenic fragment thereof, said fragment comprising at least about 5 amino acids."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 14, wherein said GapC protein comprises the amino acid sequence depicted at amino acid positions 1 to 336, inclusive, of Figures 2A-2B (SEQ ID NO:6)."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 11, wherein said GapC protein comprises the amino acid sequence of the Streptococcus uberis GapC protein depicted at amino acid positions 1 to 336, inclusive, of Figures 3A-3B (SEQ ID NO:8) or an immunogenic fragment thereof, said fragment comprising at least about 5 amino acids."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 16, wherein said GapC protein comprises the amino acid sequence depicted at amino acid positions 1 to 336, inclusive, of Figures 3A-3B (SEQ ID NO:8)."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 11, wherein said GapC protein comprises the amino acid sequence of the Streptococcus parauberis GapC protein depicted at amino acid positions 1 to 336, inclusive, of Figures 4A-4B (SEQ ID NO:10) or an immunogenic fragment thereof, said fragment comprising at least about 5 amino acids."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 18, wherein said GapC protein comprises the amino acid sequence depicted at amino acid positions 1 to 336, inclusive, of Figures 4A-4B (SEQ ID NO:10)."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 11, wherein said GapC protein comprises the amino acid sequence of the Streptococcus iniae GapC protein depicted at amino acid positions 1 to 336, inclusive, of Figures 5A-5B (SEQ ID NO:12) or an immunogenic fragment thereof, said fragment comprising at least about 5 amino acids."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 20, wherein said GapC protein comprises the amino acid sequence depicted at amino acid positions 1 to 336, inclusive, of Figures 5A-5B (SEQ ID NO:12)."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition according to any of claims 11-21, further comprising an adjuvant."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["A method of producing a vaccine composition comprising the steps of
(1) providing a GapC protein or an immunogenic fragment thereof, said fragment comprising at least about 5 amino acids, and
(2) combining said protein with a pharmaceutically acceptable vehicle."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 23, wherein the GapC protein is the protein of any of claims 1-6."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["Antibodies directed against the isolated GapC protein of any of claims 1-6."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The antibodies of claim 25 wherein said antibodies are polyclonal."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The antibodies of claim 25 wherein said antibodies are monoclonal."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["Use of a GapC protein according to any of claims 1-6, in the manufacture of a vaccine composition useful for treating or preventing a bacterial infection in a vertebrate subject."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The use of claim 28, wherein said bacterial infection is a streptococcus infection."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The use of claim 29, wherein said bacterial infection causes mastitis."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["Use of a polynucleotide according to claim 7 in the manufacture of a vaccine composition for treating or preventing a bacterial infection in a vertebrate subject"],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The use of claim 31, wherein said bacterial infection is a streptococcal infection."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["The use of claim 32, wherein said bacterial infection causes mastitis."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["Use of a GapC protein in the manufacture of a diagnostic reagent for detecting Streptococcus antibodies in a biological sample."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["Use of a GapC protein according to any of claims 1-6 in the manufacture of a diagnostic reagent for detecting Streptococcus antibodies in a biological sample."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["Use of antibodies according to any of claims 25-27 in the manufacture of a diagnostic reagent for detecting a GapC protein in a biological sample."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["An immunodiagnostic test kit for detecting Streptococcus infection, said test kit comprising a GapC protein and instructions for conducting the immunodiagnostic test."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["An immunodiagnostic test kit for detecting Streptococcus infection, said test kit comprising antibodies directed against a GapC protein and instructions for conducting the immunodiagnostic test."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating or preventing a bacterial infection in a vertebrate subject comprising administering to said subject a therapeutically effective amount of a vaccine composition according to any of claims 11-22."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said bacterial infection is a streptococcus infection."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 40, wherein said bacterial infection causes mastitis."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating or preventing a bacterial infection in a vertebrate subject comprising administering to said subject a therapeutically effective amount of a polynucleotide according to claim 7."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 42, wherein said bacterial infection is a streptococcal infection."],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 43, wherein said bacterial infection causes mastitis."],"number":44,"annotation":false,"title":false,"claim":true},{"lines":["A method of detecting Streptococcus antibodies in a biological sample, comprising:
(a) reacting said biological sample with an isolated GapC protein under conditions which allow said Streptococcus antibodies, when present in the biological sample, to bind to said GapC protein to form an antibody/antigen complex; and
(b) detecting the presence or absence of said complex, thereby detecting the presence or absence of Streptococcus antibodies in said sample."],"number":45,"annotation":false,"title":false,"claim":true},{"lines":["A method of detecting Streptococcus antibodies in a biological sample, comprising:
(a) reacting said biological sample with an isolated GapC protein according to any of claims 1-6, under conditions which allow said Streptococcus antibodies, when present in the biological sample, to bind to said GapC protein to form an antibody/antigen complex; and
(b) detecting the presence or absence of said complex, thereby detecting the presence or absence of Streptococcus antibodies in said sample."],"number":46,"annotation":false,"title":false,"claim":true},{"lines":["A method of detecting a GapC protein in a biological sample, comprising:
(a) reacting said sample with antibodies directed against the GapC protein under conditions which allow said antibodies to bind to said GapC protein, when present in the sample, to form an antibody/antigen complex; and
(b) detecting the presence or absence of said complex, thereby detecting the presence or absence of a GapC protein in said sample."],"number":47,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}