Phosphoinositide 3-kinase Inhibitor Compounds And Methods Ofuse

  • Published: Jun 12, 2008
  • Earliest Priority: Dec 07 2006
  • Family: 34
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Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geomet ric isomers, tautomers, solvates, metabolites and pharmaceutically acceptabl e salts thereof, are useful for modulating the activity of lipid kinases inc luding PI3K, and for treating disorders such as cancer mediated by lipid kin ases. Methods of using compounds of Formulas Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian ce lls, or associated pathological conditions, are disclosed. [Insert Formula I c and Id]


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