High Dosage Mucoadhesive Metronidazole Aqueous-based Gel Formulations Their Use To Treat

  • Published: Mar 3, 2016
  • Family: 21
  • Cited Works: 0
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  • Additional Info: Full text

The present disclosure relates to mucoadhesive aqueous-based homogenous gel formulations of metronidazole (MTZ) for intravaginal application and their uses, for example to treat bacterial vaginosis. Particular compositions comprise high concentration, high dosage, 1% to 2% by weight formulations providing 60mg-Omg MTZ in a single application. These compositions also reduce the incidence of vulvovaginal candidiasis, which is a common occurrence following treatment for bacterial vaginosis. Compositions also comprise mucoadhesive gelling polymers and a solvent system comprising lower aromatic alcohols, lower alkylene diols and polyoxyalkeylenes, wherein the formulation can be free from solubility enhancers such as dextrins, cyclodextrins, niacin, niacinamide and surfactants.

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Document History
  • Publication: Mar 3, 2016
  • Application: Feb 9, 2016
    AU AU 2016/200825 A
  • Priority: Feb 9, 2016
    AU AU 2016/200825 A
  • Priority: Jun 28, 2012
    AU AU 2012/275292 A
  • Priority: Jun 28, 2012
    US US 2012/0044738 W
  • Priority: Jul 14, 2011
    US US 201161508058 P
  • Priority: Jun 28, 2011
    US US 201161502285 P

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