Antibody Having Broad Neutralizing Activity In Group 1 Influenza A Virus

Abstract

 From PBMCs originating from an H1N1pdm patient, the inventors acquired three types of human monoclonal antibodies which bind to epitopes present at positions 40-58 of the HA2 region of an H1N1pdm-derived hemagglutinin protein. The inventors also discovered that these antibodies have neutralizing activity with respect to the H1 subtype and the H5 subtype of group 1 influenza A virus. The inventors also discovered that the three types of antibodies have neither affinity nor neutralizing activity with respect to the H2 subtype, which belongs to group 1 but has the amino acid at position 45 substituted with phenylalanine and the amino acid at position 47 substituted with glycine in the H1N1pdm-derived HA2 region.


Claims

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