Mutant Rex Transdominant Repressors Of Hiv Replication

Abstract

Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex function in HTLV-I and HTLV-II and, in some cases, both the Rev and the Rex function and are, therefore, active in more than one viral species. Such transdominant viral mutants are useful as anti-viral agents to, for example protect cells against the deleterious effects of viral, e.g. HIV-1, infection.


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Document History
  • Publication: Sep 11, 2001
  • Application: Dec 30, 1998
    US US 22424798 A
  • Priority: Dec 30, 1998
    US US 22424798 A
  • Priority: Nov 3, 1994
    US US 33370394 A
  • Priority: Apr 2, 1993
    US US 4237993 A
  • Priority: Nov 29, 1989
    US US 44267089 A
  • Priority: Oct 30, 1989
    GB GB 8924396 A
  • Priority: Jul 7, 1989
    GB GB 8915602 A
  • Priority: May 25, 1989
    US US 35687889 A

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