Antibody Induced Cell Membrane Wounding

Abstract

Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated with the cytoskeleton of the cell. A preferred polyvalent agent is an IgM, and enhanced cell wounding and killing can be provided by the addition of a crosslinking agent. At sublethal concentrations in vivo, the cell wounding antibodies permeabilize cells and dramatically enhance response to chemotherapeutic agents, even in patients refractory to the chemotherapeutic agents.


Claims
Download PDF
Document Preview
Document History
  • Publication: Oct 4, 2016
  • Application: Feb 19, 2013
    US US 201313770619 A
  • Priority: Feb 19, 2013
    US US 201313770619 A
  • Priority: Nov 4, 2005
    US US 26793505 A
  • Priority: Nov 5, 2004
    US US 62539804 P
  • Priority: Nov 5, 2004
    US US 98269804 A

Download Citation


Sign in to the Lens

Feedback