Modulation Of Synaptic Maintenance

Abstract

C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including treating and preventing neurodegenerative diseases such as Alzheimer's disease.


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Document History
  • Publication: Mar 26, 2019
  • Application: Jul 28, 2016
    US US 201615222603 A
  • Priority: Jul 28, 2016
    US US 201615222603 A
  • Priority: Aug 15, 2012
    US US 201213586556 A
  • Priority: Dec 14, 2011
    US US 201113326180 A
  • Priority: Aug 15, 2011
    US US 201161523702 P
  • Priority: Dec 8, 2006
    US US 63600106 A
  • Priority: Dec 9, 2005
    US US 74907105 P

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