Method Of Screening Oxysterol Activation Of Lxralpha

Abstract

The present invention provides a method of screening for agonists of an oxycholesterol activator of LXRalpha transcription, comprising the steps of: introducing a reporter construct and an LXR expression construct into a host cell; treating the host cell with potential LXR-specific ligands; and identifying compounds which activate LXRalpha transcription. Also provided is a method of screening for antagonists of an oxycholesterol activator of LXRalpha transcription, comprising the steps of: introducing a reporter construct and an LXR expression construct into a host cell; pretreating the host cell with activators of LXRalpha transcription; contacting the host cell with potential antagonists of LXRalpha transcription; and identifying compounds which block the activation the LXRalpha transcription.


Claims
Owners (US)

Information currently unavailable.

Download PDF
Document Preview
Document History
  • Publication: May 17, 2005
  • Application: Jun 23, 2000
    US US 60313100 A
  • Priority: Jun 23, 2000
    US US 60313100 A
  • Priority: Sep 26, 1997
    US US 94393697 A
  • Priority: Sep 27, 1996
    US US 2679696 P

Download Citation


Sign in to the Lens

Feedback