Screening Compounds For Activity In Modulating Chloride Ion Transport


A method for screening a test compound for activity in modulating the activity of the chloride channel ClC-7 either directly or by modulating the subcellular localization of Ostm1 comprises determining whether test compound inhibits the binding of Ostm1 to ClC-7. Compounds active in the screen are candidates for use in treating bone resorption conditions such as Osteoporosis by modulating the activity of osteoclasts.

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Document History
  • Publication: Dec 14, 2010
  • Application: Dec 18, 2006
    US US 8672606 A
  • Priority: Dec 18, 2006
    EP EP 2006069829 W
  • Priority: Dec 20, 2005
    GB GB 0525898 A

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