Immunologically Significant Herpes Simplex Virus Antigens And Methods For Identifying And Using Same

Abstract

The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.


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Document History
  • Publication: Nov 8, 2005
  • Application: Apr 5, 2002
    US US 11747602 A
  • Priority: Apr 5, 2002
    US US 11747602 A
  • Priority: Sep 28, 2000
    US US 67259500 A
  • Priority: Jul 13, 2000
    US US 21810400 P
  • Priority: May 12, 2000
    US US 20366000 P
  • Priority: Sep 30, 1999
    US US 15718199 P

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