Recombinant Bicistronic Flaviviruses And Methods Of Use Thereof


The present invention provides recombinant bicistronic flaviviruses, particularly live attenuated recombinant bicistronic flavivirus, which comprise, in order from 5′ to 3′, a viral 5′UTR, an ORF encoding all viral proteins, an internal ribosome entry site, an exogenous nucleotide sequence that encodes an exogenous polypeptide, and a viral 3′UTR. Infection of a host cell with a recombinant flavivirus provides for expression of the exogenous nucleic acid in a host cell. Such recombinant flavivirus are useful for delivering a protein to a mammalian host; and for eliciting an immune response to the exogenous polypeptide.

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Document History
  • Publication: Apr 24, 2012
  • Application: Nov 23, 2010
    US US 95317410 A
  • Priority: Nov 23, 2010
    US US 95317410 A
  • Priority: Jul 14, 2004
    US US 47750404 A
  • Priority: May 9, 2002
    US US 0214783 W
  • Priority: May 10, 2001
    US US 29041201 P

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