{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"193-663-443-272-563","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"193-663-443-272-563"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11703,"type":"PATENT","title":"Tel Aviv University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":6197,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8357,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: tel aviv uni*
Select more for logical variants.
Add to collection.
Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 4719
Search Applicants and Owners separately: tel aviv uni*
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Add to collection.
Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 4719
R1 represents farnesyl, geranyl or geranyl-geranyl;\n
Z represents C—R6 or N;\n
R2 represents H, CN, the groups COOR7, SO3R7, CONR7R8, COOM, SO3M and SO2NR7R8, wherein R7 and R8 are each independently hydrogen, alkyl or alkenyl, and wherein M is a cation;\n
R3 , R4, R5 and R6 are each independently hydrogen, carboxyl, alkyl, alkenyl, aminoalkyl, nitroalkyl, nitro, halo, amino, mono- or di-alkylamino, mercapto, mercaptoalkyl, axido, or thiocyanato;\n
X represents O, S, SO, SO2, NH or Se; and\n
the quaternary ammonium salts and N-oxides of the compounds of said formula when Z is N."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is farnesyl-thiosalicyclic acid (FTS)."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is 2-chloro-5-farnesylaminobenzoic acid (NFCB)."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is farnesyl thionicotinic acid (FTN)."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is 5-fluoro-FTS."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is 5-chloro-FTS."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is 4-chloro-FTS."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is S-farnesyl-thiosalicylic acid methyl ester."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is administered parenterally."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is administered orally."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is administered prophylactically."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is administered in a formulation containing a cyclodextrin."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras is activated Ras."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the vascular injury is post-angioplasty restenosis."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14 wherein the Ras antagonist is administered prophylactically."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the vascular injury is atherosclerosis."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is represented by the formula \n\n
wherein\n
R1 represents farnesyl, geranyl or geranyl-geranyl;\n
Z represents C—R6;\n
R2 represents H, CN, the groups COOR7, SO3R7, CONR7R8, COOM, SO3M and SO2NR7R8, wherein R7 and R8 are each independently hydrogen, alkyl or alkenyl, and wherein M is a cation;\n
R3, R4, R5 and R6 are each independently hydrogen, carboxyl, alkyl, akenyl, aminoalkyl, nitroalkyl, nitro, halo, amino, mono- or di-alkylamino, mercapto, mercaptoalkyl, axido, or thiocyanato; and\n
X represents O, S, SO, SO2, NH or Se."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the Ras antagonist is represented by the formula \n\n
wherein\n
R1 represents farnesyl, geranyl or geranyl-geranyl;\n
Z represents C—R6;\n
R2 represents CN, the groups COOR7, SO3R7, CONR7R8, COOM, SO3M and SO2NR7R8, wherein R7 and R8 are each independently hydrogen alkyl or alkenyl, and wherein M is a cation;\n
R3, R4, R5 and R6 are each independently hydrogen, carboxyl, alkyl, alkenyl, aminoalkyl, nitroalkyl, nitro, halo, amino, mono- or di-alkylamino, mercapto, mercaptoalkyl, axido, or thiocyanato; and\n
X represents O, S, SO, SO2, NH or Se."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, wherein the vascular injury is atherosclerosis."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, wherein the vascular injury is post-angioplasty restenosis."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, wherein the Ras antagonist is administered prophylactically."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, 19 or 20 wherein the Ras antagonist is administered orally."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 5, wherein the vascular injury is atherosclerosis."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 5, wherein the vascular injury is post-angioplasty restenosis."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 5, wherein the Ras antagonist is administered prophylactically."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 5, 23 or 24 wherein the Ras antagonist is administered orally."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 6, wherein the vascular injury is atherosclerosis."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 6, wherein the vascular injury is post-angioplasty restenosis."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 6, wherein the Ras antagonist is administered prophylactically."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 6, 27 or 28 wherein the Ras antagonist is administered orally."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7, wherein the vascular injury is atherosclerosis."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7, wherein the vascular injury is post-angioplasty restenosis."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7, wherein the Ras antagonist is administered prophylactically."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7, 31 or 32 wherein the Ras antagonist is administered orally."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein the vascular injury is atherosclerosis."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein the vascular injury is post-angioplasty restenosis."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein the Ras antagonist is administered prophylactically."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, 35, or 36 wherein the Ras antagonist is administered orally."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["The method of any one of claims 1-16, wherein the mammal is a human."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The method of any one of claims 17-21, wherein the mammal is human."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 22, wherein the mammal is a human."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The method of any one of claims 23-25, wherein the mammal is a human."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 26, wherein he mammal is a human."],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The method of any one of claims 27-29, wherein the mammal is a human."],"number":44,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 30, wherein he mammal is a human."],"number":45,"annotation":false,"title":false,"claim":true},{"lines":["The method of any one of claims 31-33, wherein the mammal is a human."],"number":46,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 34, wherein he mammal is a human."],"number":47,"annotation":false,"title":false,"claim":true},{"lines":["The method of any one of claims 35-37, wherein the mammal is a human."],"number":48,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 38, wherein the mammal is a human."],"number":49,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}