{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"192-868-049-723-12X","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"192-868-049-723-12X"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11797,"type":"PATENT","title":"Queen's University at Kingston Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":5666,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8427,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: queen* AND univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1261
Search Applicants and Owners separately: queen* AND univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1261
n is 1;\n
X and Y are each independently selected from the group consisting of —C(O)—, —C (S)—, —C(NR34)—, —S(O)—, and —S(O)2— where R34 is hydrogen or an alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties;\n
Z is a 2-cyano-pyrrolidin-1-yl;\n
R1 and R2 are each hydrogen;\n
R3 is selected from the group consisting of hydrogen, (C1-10)alkyl, hydroxy, alkoxy, and amino, wherein said alkyl group is unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties;\n
R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-10)alkyl, alkoxy, cyano, halo, and nitro, wherein said alkyl and alkoxy groups are unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties; and\n
R7 is amino, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein X and Y are each independently selected from the group consisting of C(O), C(NH), S(O) and S(O)2."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein Y is C(O) and X is selected from the group consisting of C(O), C(NH), S(O) and S(O)2."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["A compound of the formula:\nwherein\n
n is 1;\n
X and Y are each independently selected from the group consisting of —C(O)—, —C(S)—, —C(NR34)—, —S(O)—, and —S(O)2— where R34 is hydrogen or an alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties;\n
Z is 1-pyrrolidinyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, eteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, cyano, oxaalkyl, and oxoalkyl moieties;\n
R1 and R2 are each hydrogen;\n
R3 is selected from the group consisting of hydrogen, (C1-10)alkyl, hydroxy, alkoxy, and amino, wherein said alkyl group is unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties;\n
R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-10)alkyl, alkoxy, cyano, halo, and nitro, wherein said alkyl and alkoxy groups are unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties; and\n
R7 is of the formula —NR14R15 where R14 is a —(C3-12)cycloalkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties, and R15 is selected from the group consisting of hydrogen and (C1-8)alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["A compound of the formula:\nwherein\n
n is 1;\n
X and Y are each independently selected from the group consisting of —C(O)—, —C(S) —, —C(NR34)—, —S(O)—, and —S(O)2— where R34 is hydrogen or an alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties;\n
Z is 1-pyrrolidinyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, cyano, oxaalkyl, and oxoalkyl moieties;\n
R1 and R2 are each hydrogen;\n
R3 is selected from the group consisting of hydrogen, (C1-10)alkyl, hydroxy, alkoxy, and amino, wherein said alkyl group is unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties;\n
R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-10)alkyl, alkoxy, cyano, halo, and nitro, wherein said alkyl and alkoxy groups are unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties; and\n
R7 is of the formula —NR14R15 where R14 is hetero (C3-12)cycloalkyl and R15 is selected from the group consisting of hydrogen and (C1-8)alkyl, wherein said heterocycloalkyl and alkyl are unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["A compound of the formula:\nwherein\n
n is 1;\n
X and Y are each independently selected from the group consisting of —C(O)—, —C(S)—, —C(NR34)—, —S(O)—, and —S(O)2— where R34 is hydrogen or an alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties;\n
Z is 1-pyrrolidinyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, cyano, oxanikyl, and oxoalkyl moieties;\n
R1 and R2 are each hydrogen;\n
R3 is selected from the group consisting of hydrogen, (C1-10)alkyl, hydroxy, alkoxy, and amino, wherein said alkyl group is unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties;\n
R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-10 )alkyl, alkoxy, cyano, halo, and nitro, wherein said alkyl and alkoxy groups are unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties; and\n
R7 is of the formula —NR14R15 where R14 is (C6-12)aryl or hetero(C5-12)aryl and R15 is selected from the group consisting of hydrogen and (C1-8)alkyl, wherein said aryl, heteroaryl and alkyl are unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A compound of the formula:\nwherein\n
n is 1;\n
X and Y are each independently selected from the group consisting of —C(O)—, —C(S)—, —C(NR34)—, —S(O)—, and —S(O)2— where R34 is hydrogen or an alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, cyano, oxaalkyl, and oxoalkyl moieties;\n
Z is 1-pyrrolidinyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties;\n
R1 and R2 are each hydrogen;\n
R3 is selected from the group consisting of hydrogen, (C1-10)alkyl, hydroxy, alkoxy, and amino, wherein said alkyl group is unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxanikyl, and oxoalkyl moieties;\n
R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-10)alkyl, alkoxy, cyano, halo, and nitro, wherein said alkyl and alkoxy groups are unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties; and\n
R7 is of the formula —NR14R15 where R14 is (C9-12)bicycloaryl or hetero(C8-12)bicycloaryl and R15 is selected from the group consisting of hydrogen and (C1-8)alkyl, wherein said bicycloaryl, herteobicycloaryl and alkyl are unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein at least one of R5 and R6 is —(C1-8)alkyleneR23, wherein R23 is selected from the group consisting of (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C4-12)cycloalkyl, (C6-12)aryl, hetero(C5-12)aryl, (C9-12)bicycloalkyl, hetero(C9-12)bicycloalkyl, (C9-12)bicycloaryl and hetero(C8-12)bicycloaryl, each being unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein at least one of R5 and R6 is selected from the group consisting of —OR23 or —(C1-8)alkyleneR23, each being unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties, wherein R23 is selected from the group consisting of (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C4-12)cycloalkyl, (C6-12)aryl, hetero(C5-12)aryl, (C9-12)bicycloalkyl, hetero(C9-12)bicycloalkyl, (C9-12)bicycloaryl and hetero(C8-12)bicycloaryl."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein at least one of R5 and R6 is substituted through available atoms by one to three radicals selected from the group consisting of —NH2, —NHC(NH)NH2, —OH, —SH, —C(O)OH and —C(O)NH2."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein at least one of R5 and R6 is hydrogen."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein both R5 and R6 are hydrogen."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein R3 is hydrogen."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein R3 is (C1-10)alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A compound selected from the group consisting of:\n
2-[(S)-2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-N-phenyl-acetamide;\n
2-[(S)-2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-N-(4-fluoro-phenyl)-acetamide;\n
2-[(S)-2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-N-pyridin-4-yl-acetamide;\n
2-[(S)-2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-N-(4-methoxy-phenyl)-acetamide;\n
3-{(S)-2-[2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-acetylamino}-benzoic acid;\n
4-{(S)-2-[2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-acetylamino}-benzoic acid;\n
2-[(S)-2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-N-cyclohexyl-acetamide;\n
N-Benzyl-2-[(S)-2-(2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-acetamide;\n
{(S)-2-[2-((S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-acetylamino}-phenyl-acetic acid methyl ester;\n
2-{2-[(S)-2-Cyano-pyrrolidin-1-yl]-2-oxo-ethylamino}-N-[(R)-1-hydroxymethyl-2-methyl-propyl ]-acetamide; and\n
1-{2-[(S)-2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-acetylamino}-cyclopropanecarboxylic acid."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein the compound is in the form of a pharmaceutically acceptable salt."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein the compound is present in a mixture of stereoisomers."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 1 wherein the compound is present as a single stereoisomer."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 4 wherein Z is selected from the group consisting of 2-cyano-pyrrolidin-1-yl and 4-fluoro-2-cyanopyrrolidin-1-yl."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 4 wherein at least one of R5 and R6 is —(C1-8)alkyleneR23, wherein R23 is selected from the group consisting of (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C4-12)cycloalkyl, (C6-12)aryl, hetero(C5-12)aryl, (C9-12)bicycloalkyl, hetero(C9-12)bicycloalkyl, (C9-12)bicycloaryl and hetero(C8-12)bicycloaryl, each being unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 4 wherein at least one of R5 and R6 is selected from the group consisting of —OR23 or —(C1-8)alkyleneR23, each being unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties, wherein R23 is selected from the group consisting of (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C4-12)cycloalkyl, (C6-12)aryl, hetero(C5-12)aryl, (C9-12)bicycloalkyl, hetero(C9-12)bicycloalkyl, (C9-12)bicycloaryl and hetero(C8-12)bicycloaryl."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 4 wherein at least one of R5 and R6 is substituted through available atoms by one to three radicals selected from the group consisting of —NH2, —NHC(NH)NH2, —OH, —SH, —C(O)OH and —C(O)NH2."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 4 wherein at least one of R5 and R6 is hydrogen."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 4 wherein both R5 and R6 are hydrogen."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 4 wherein R3 is hydrogen."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 4 wherein R3 is (C1-10)alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 5 wherein Z is selected from the group consisting of 2-cyano-pyrrolidin-1-yl and 4-fluoro-2-cyanopyrrolidin-1-yl."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 5 wherein at least one of R5 and R6 is —(C1-8)alkyleneR23, wherein R23 is selected from the group consisting of (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C4-12)cycloalkyl, (C6-12)aryl, hetero(C5-12)aryl, (C9-12)bicycloalkyl, hetero(C9-12)bicycloalkyl, (C9-12)bicycloaryl and hetero (C8-12)bicycloaryl, each being unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 5 wherein at least one of R5 and R6 is selected from the group consisting of —OR23 or —(C1-8)alkyleneR23, each being unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxanikyl, and oxoalkyl moieties, wherein R23 is selected from the group consisting of (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C4-12)cycloalkyl, (C6-12)aryl, hetero(C5-12)aryl, (C9-12)bicycloalkyl, hetero(C9-12)bicycloalkyl, (C9-12)bicycloaryl and hetero(C8-12)bicycloaryl."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 5 wherein at least one of R5 and R6 is substituted through available atoms by one to three radicals selected from the group consisting of —NH2, —NHC(NH)NH2, —OH, —SH, —C(O)OH and —C(O)NH2."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 5 wherein at least one of R5 and R6 is hydrogen."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 5 wherein both R5 and R6 are hydrogen."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 5 wherein R3 is hydrogen."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 5 wherein R3 is (C1-10)alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 6 wherein Z is selected from the group consisting of 2-cyano-pyrrolidin-1-yl and 4-fluoro-2-cyanopyrrolidin-1-yl."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 6 wherein at least one of R5 and R6 is —(C1-8)alkyleneR23, wherein R23 is selected from the group consisting of (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C4-12)cycloalkyl, (C6-12)aryl, hetero(C5-12)aryl, (C9-)bicycloalkyl, hetero(C9-12)bicycloalkyl, (C9-12)bicycloaryl and hetero(C8-12)bicycloaryl, each being unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 6 wherein at least one of R5 and R6 is selected from the group consisting of —OR23 or —(C1-8)alkyleneR23, each being unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties, wherein R23 is selected from the group consisting of (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C4-12)cycloalkyl, (C6-12)aryl, hetero(C5-12)aryl, (C9-12)bicycloalkyl, hetero(C9-12)bicycloalkyl, (C9-12)bicycloaryl and hetero(C8-12)bicycloaryl."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 6 wherein at least one of R5 and R6 is substituted through available atoms by one to three radicals selected from the group consisting of —NH2, —NHC(NH)NH2, —OH, —SH, —C(O)OH and —C(O)NH2."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 6 wherein at least one of R5 and R6 is hydrogen."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 6 wherein both R5 and R6 are hydrogen."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 6 wherein R3 is hydrogen."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 6 wherein R3 is (C1-10)alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 7 wherein Z is selected from the group consisting of 2-cyano-pyrrolidin-1-yl and 4-fluoro-2-cyanopyrrolidin-1-yl."],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 7 wherein at least one of R5 and R6 is —(C1-8)alkyleneR23, wherein R23 is selected from the group consisting of (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C4-12)cycloalkyl, (C6-12 )aryl, hetero(C5-12)aryl, (C9-12)bicycloalkyl, hetero(C9-12)bicycloalkyl, (C9-12)bicycloaryl and hetero(C8-12)bicycloaryl, each being unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":44,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 7 wherein at least one of R5 and R6 is selected from the group consisting of —OR23 or —(C1-8)alkyleneR23, each being unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties, wherein R23 is selected from the group consisting of (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C4-12)cycloalkyl, (C6-12)aryl, hetero(C5-12)aryl, (C9-12)bicycloalkyl, hetero(C9-12)bicycloalkyl, (C9-12)bicycloaryl and hetero(C8-12)bicycloaryl."],"number":45,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 7 wherein at least one of R5 and R6 is substituted through available atoms by one to three radicals selected from the group consisting of —NH2, —NHC(NH)NH2, —OH, —SH, —C(O)OH and —C(O)NH2."],"number":46,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 7 wherein at least one of R5 and R6 is hydrogen."],"number":47,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 7 wherein both R5 and R6 are hydrogen."],"number":48,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 7 wherein R3 is hydrogen."],"number":49,"annotation":false,"title":false,"claim":true},{"lines":["The compound according to claim 7 wherein R3 is (C1-10)alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties."],"number":50,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}