Method For Forming Disulfide Bridges


The invention relates to an improved method for forming disulfide bridges in substances carrying SH groups, especially peptides, for example by forming intramolecular disulfide bridges. According to said method, a heterocyclic compound (for example caffeine or a caffeine-type substance) comprising at least one nitrogen atom is used for the catalysis of the reaction. Surprisingly, it has been found that the addition of the heterocyclic substance increases both the yield and the purity of the product carrying disulfide bridges.

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Document History
  • Publication: Jul 3, 2008
  • Application: Dec 21, 2007
    WO EP 2007011362 W
  • Priority: Jul 11, 2007
    EP EP 07013584 A
  • Priority: Jul 11, 2007
    US US 94908207 P
  • Priority: Dec 23, 2006
    EP EP 2006012526 W

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